Evidence map›Paper›PMID 29106626›Full record

ArticleNucleic acids research2018

PAMDB: a comprehensive Pseudomonas aeruginosa metabolome database.

Weiliang Huang, Luke K Brewer, Jace W Jones, Angela T Nguyen, Ana Marcu, David S Wishart, Amanda G Oglesby-Sherrouse, Maureen A Kane, Angela Wilks

Open access · goldAbstract read
In one paragraph

Article in Nucleic acids research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 63 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. mBio · 2024
    Article
  10. Article
  11. Article
  12. Article
  13. Enzyme Databases in the Era of Omics and Artificial Intelligence.International journal of molecular sciences · 2023
    Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Discovering New Natural Products Using Metabolomics-Based Approaches.Advances in experimental medicine and biology · 2023
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Weiliang HuangDepartment of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD 21209, USA.
Luke K BrewerDepartment of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD 21209, USA.
Jace W JonesDepartment of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD 21209, USA.
Angela T NguyenDepartment of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD 21209, USA.
Ana MarcuDepartment of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E9, Canada.
David S WishartDepartment of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E9, Canada.
Amanda G Oglesby-SherrouseDepartment of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD 21209, USA.
Maureen A KaneDepartment of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD 21209, USA.
Angela WilksDepartment of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD 21209, USA.
University of Maryland, Baltimore · USUniversity of Alberta · CA

Funding

Graduate Training at The Chemistry Biology InterfaceT32GM066706 · NIGMS · UNIVERSITY OF MARYLAND BALTIMORE COUNTY · PI SELEY-RADTKE, KATHERINE L, SMITH, AARON T · 2004 to 2023
$3.3M
Role of PrrF and PrrH regulation in Pseudomonas aeruginosa pathogenesisR01AI123320 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI OGLESBY, AMANDA GAIL · 2016 to 2020
$2.2M
Heme utilization and homeostasis in Pseudomonas aeruginosaR01AI102883 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI WILKS, ANGELA · 2013 to 2017
$2.0M
NIAID NIH HHS R01 AI102883NIAID NIH HHS R01 AI123320NIGMS NIH HHS T32 GM066706
6 · The paper itself

Abstract

The Pseudomonas aeruginosaMetabolome Database (PAMDB, http://pseudomonas.umaryland.edu) is a searchable, richly annotated metabolite database specific to P. aeruginosa. P. aeruginosa is a soil organism and significant opportunistic pathogen that adapts to its environment through a versatile energy metabolism network. Furthermore, P. aeruginosa is a model organism for the study of biofilm formation, quorum sensing, and bioremediation processes, each of which are dependent on unique pathways and metabolites. The PAMDB is modelled on the Escherichia coli (ECMDB), yeast (YMDB) and human (HMDB) metabolome databases and contains >4370 metabolites and 938 pathways with links to over 1260 genes and proteins. The database information was compiled from electronic databases, journal articles and mass spectrometry (MS) metabolomic data obtained in our laboratories. For each metabolite entered, we provide detailed compound descriptions, names and synonyms, structural and physiochemical information, nuclear magnetic resonance (NMR) and MS spectra, enzymes and pathway information, as well as gene and protein sequences. The database allows extensive searching via chemical names, structure and molecular weight, together with gene, protein and pathway relationships. The PAMBD and its future iterations will provide a valuable resource to biologists, natural product chemists and clinicians in identifying active compounds, potential biomarkers and clinical diagnostics.

Indexed as

Databases, FactualMetabolomicsData CurationMetabolic Networks and PathwaysMetabolomePseudomonas aeruginosaSearch EngineUser-Computer Interface

Identifiers

PMID29106626
PMCPMC5753269
OpenAlexW2766295385

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.