ArticleThe Journal of antimicrobial chemotherapy2018
Origin of the plasmid-mediated fosfomycin resistance gene fosA3.
Article in The Journal of antimicrobial chemotherapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed.
- Pan-immune system, mobilome and resistome inMicrobial genomics · 2025Article
- Salmonella isolated from street foods and environment of an urban park: A whole genome sequencing approach.PloS one · 2025Article
- Reporting two novelFrontiers in microbiology · 2025Article
- Overcoming the drug resistance barrier: progress in fosfomycin combination therapy against multidrug-resistant pathogens.Frontiers in microbiology · 2025Review
- ISMicrobiology and molecular biology reviews : MMBR · 2024Review
- Bacteriological and molecular study of fosfomycin resistance in uropathogenic Escherichia coli.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024Article
- In vitro susceptibility to fosfomycin in clinical and environmental extended-spectrum beta-lactamase producing and/or ciprofloxacin-non-susceptible Escherichia coli isolates.Revista do Instituto de Medicina Tropical de Sao Paulo · 2024Article
- Evidence for wastewaters as environments where mobile antibiotic resistance genes emerge.Communications biology · 2023Article
- Emergence of Fosfomycin Resistance by Plasmid-MediatedAntibiotics (Basel, Switzerland) · 2022Article
- Resensitization of Fosfomycin-ResistantInternational journal of molecular sciences · 2022Article
- Antibiotic resistance genes are differentially mobilized according to resistance mechanism.GigaScience · 2022Article
- A framework for identifying the recent origins of mobile antibiotic resistance genes.Communications biology · 2021Article
- Chromosomally LocatedFrontiers in microbiology · 2021Article
- Mobile fosfomycin resistance genes in Enterobacteriaceae-An increasing threat.MicrobiologyOpen · 2020Review
- Multiple Plasmid Vectors Mediate the Spread ofmSphere · 2020Article
- Characterization of FosL1, a Plasmid-Encoded Fosfomycin Resistance Protein Identified in Escherichia coli.Antimicrobial agents and chemotherapy · 2020Article
- Article
- Identification of FosA8, a Plasmid-Encoded Fosfomycin Resistance Determinant from Escherichia coli, and Its Origin in Leclercia adecarboxylata.Antimicrobial agents and chemotherapy · 2019Article
- New microbiological aspects of fosfomycin.Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2019Review
- Proposing Kluyvera georgiana as the Origin of the Plasmid-Mediated Resistance GeneAntimicrobial agents and chemotherapy · 2018Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Background: fosA3 is the most commonly reported plasmid-mediated fosfomycin resistance gene among Enterobacteriaceae. Objectives: To identify the origin of fosA3. Methods: The chromosome of Kluyvera georgiana clinical strain YDC799 was fully sequenced with single-molecule real-time sequencing. Comparative genetic analysis was performed for K. georgiana YDC799, K. georgiana type strain ATCC 51603 and representative fosA3-carrying plasmids. fosA genes were cloned in Escherichia coli to confirm function. Results: K. georgiana YDC799 harboured fosA (designated fosAKG) and blaCTX-M-8 on the chromosome. The genetic environments surrounding fosA3 and bounded by IS26 were nearly identical with the corresponding regions of K. georgiana YDC799 and ATCC 51603. The amino acid sequence of FosAKG from YDC799 and K. georgiana ATCC 51603 shared 99% and 94% identity with FosA3, respectively. Cloned FosAKG conferred fosfomycin resistance with an MIC of >1024 mg/L for E. coli. Conclusions: The plasmid-mediated fosA3 gene was likely mobilized from the chromosome of K. georgiana by an IS26-mediated event.
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