ArticleNature medicine2017
Asprosin is a centrally acting orexigenic hormone.
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Article in Nature medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 179 papers, 4 of them syntheses that pooled it.
0numbers the graph read from it
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179citing papers in PubMed, 4 pooled it
10.4field-weighted citation impact, top 1% of its field
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
179 citing papers in PubMed, 4 syntheses or guidelines pooled it, 336 citations in OpenAlex.
- Systematic review and meta-analysis of the effect of exercise training on asprosin in randomized controlled trials.Physiological reports · 2025Pooled it
- Relationship of asprosin and diabetes: a meta-analysis.BMC endocrine disorders · 2025Pooled it
- Circulating levels of asprosin in children with obesity: a systematic review and meta-analysis.BMC endocrine disorders · 2024Pooled it
- Pooled it
- Spirulina supplementation and circuit resistance training (CRT) reduce serum asprosin and appetite and improve energy balance in men with obesity and overweight.Hormones (Athens, Greece) · 2025Trial
- Effects of exercise and dietary interventions on asprosin, leptin, and lipid metabolism in males with abdominal obesity, a randomized controlled trial.Scientific reports · 2024Trial
- Exercise-induced effects on asprosin and indices of atherogenicity and insulin resistance in males with metabolic syndrome: a randomized controlled trial.Scientific reports · 2024Trial
- CYP1A2 polymorphisms modify the association of habitual coffee consumption with appetite, macronutrient intake, and body mass index: results from an observational cohort and a cross-over randomized study.International journal of obesity (2005) · 2022Trial
- The serum level of irisin, but not asprosin, is abnormal in polycystic ovary syndrome patients.Scientific reports · 2019Trial
- Curcumin modulates the adipose FBN1-Asprosin axis and improves metabolic dysfunction in a rat model of type 2 diabetes.Metabolism open · 2026Article
- Asprosin-driven metabolic-epigenetic rewiring attenuates mesenchymal stem cell senescence with therapeutic benefits for infarcted hearts.Journal of advanced research · 2026Article
- Adipose tissue as a humoral-neuronal hub in metabolic regulation.Nature reviews. Endocrinology · 2026Review
- Observational
- Gingival crevicular fluid asprosin, adropin, and irisin hormone levels in the different periodontal status.Clinical oral investigations · 2026Article
- Aortic asprosin overexpression does not ameliorate disease pathophysiology in a murine model of Marfan syndrome.Scientific reports · 2026Article
- Asprosin-PTPRD endocrine resistance links brain dysfunction and systemic wasting in Alzheimer's disease.Research square · 2026Article
- Endocrine regulation of the hepatic fasting response: cues, cooperation and consequences.Nature reviews. Endocrinology · 2026Review
- Circulating Asprosin Concentrations and Body Weight Changes in Postmenopausal Women: Findings from the Women's Health Initiative.The Journal of nutrition · 2026Article
- Expression of asprosin and OLFR734 in reproductive tissues of polycystic ovary syndrome mice: insights into metabolic and reproductive dysfunction.Cell and tissue research · 2026Article
- YY1/Asprosin/PFKP axis regulates glycolytic metabolic and exacerbates pathological cardiac hypertrophy.Nature communications · 2026Article
119 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
21 authors at 5 institutions in 1 country.
Clemens DuerrschmidDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA.ORCID http://orcid.org/0000-0001-7718-5152
Yanlin HeUSDA-ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA.ORCID http://orcid.org/0000-0002-5471-9016
Chunmei WangUSDA-ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA.
Chia LiDiabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health (NIH), Bethesda, Maryland, USA.
Juan C BournatDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA.
Chase RomereDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA.ORCID http://orcid.org/0000-0002-6633-8077
Pradip K SahaDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA.
Mark E LeeDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA.
Kevin J PhillipsDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA.
Mahim JainKennedy Krieger Institute, Baltimore, Maryland, USA.
Peilin JiaCenter for Precision Health, School of Biomedical Informatics, University of Texas Health Science Center at Houston, Houston, Texas, USA.
Zhongming ZhaoCenter for Precision Health, School of Biomedical Informatics, University of Texas Health Science Center at Houston, Houston, Texas, USA.ORCID http://orcid.org/0000-0002-3477-0914
Monica FariasUSDA-ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA.
Qi WuUSDA-ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA.
Dianna M MilewiczDepartment of Internal Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, Texas, USA.
V Reid SuttonDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA.
David D MooreDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA.
Nancy F ButteUSDA-ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA.
Michael J KrashesDiabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health (NIH), Bethesda, Maryland, USA.
Yong XuDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA.ORCID http://orcid.org/0000-0002-4908-1572
Atul R ChopraDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA.
Baylor College of Medicine · USChildren's Nutrition Research Center at Baylor College of Medicine · USNational Institutes of Health · USThe University of Texas Health Science Center at Houston · USKennedy Krieger Institute · US
Funding
Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI David Darr · 1985 to 2026
$201.5MTumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI PAVAN REDDY · 2007 to 2026
$73.9MUM1HG006348: Cas9 Genome Integrity Supplemental ProposalUM1HG006348 · NHGRI · BAYLOR COLLEGE OF MEDICINE · PI Jason D. Heaney, Chih-Wei Logan Hsu · 2016 to 2026
$47.5MBaylor-Johns Hopkins Center for Mendelian GeneticsUM1HG006542 · NHGRI · JOHNS HOPKINS UNIVERSITY · PI VALLE, DAVID · 2016 to 2020
$14.5MDiabetes Endocrinology Research CenterP30DK079638 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI CHAN, LAWRENCE · 2008 to 2012
$6.4MInvestigating the interaction of motivational systemsZIADK075090 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI KRASHES, MICHAEL J. · 2013 to 2025
$4.7MUnraveling hippocampal networks related to food memoriesZIADK075089 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI KRASHES, MICHAEL J. · 2013 to 2025
$4.7MInvestigating addictive/compulsive feeding behaviorZIADK075088 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI KRASHES, MICHAEL J. · 2013 to 2025
$4.7MProbing neural circuits underlying satietyZIADK075087 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI KRASHES, MICHAEL J. · 2013 to 2025
$4.7MTransforming dbGaP genetic and genomic data to FAIR-ready by artificial intelligence and machine learning algorithmsR01LM012806 · NLM · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Zhongming Zhao · 2017 to 2026
$3.7MThe Requirement for TR Signaling in Beige Adipocyte FunctionR01DK111631 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI PHILLIPS, KEVIN JOHN · 2017 to 2021
$2.0MCNS Circuits Mediating Estrogenic Regulation on Energy and Glucose HomeostasisR01DK093587 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI XU, YONG · 2011 to 2015
$1.6MNCI NIH HHS P30 CA016086NCI NIH HHS P30 CA125123NHGRI NIH HHS UM1 HG006348NHGRI NIH HHS UM1 HG006542NIDDK NIH HHS K08 DK102529NIDDK NIH HHS P30 DK079638NIDDK NIH HHS R01 DK093587NIDDK NIH HHS R01 DK101379NIDDK NIH HHS R01 DK111631NIDDK NIH HHS R56 DK109194NLM NIH HHS R01 LM012806
Abstract
Asprosin is a recently discovered fasting-induced hormone that promotes hepatic glucose production. Here we demonstrate that asprosin in the circulation crosses the blood-brain barrier and directly activates orexigenic AgRP
Indexed as
AdipokinesAdolescentAdultAnimalsAppetite DepressantsAppetite RegulationFemaleFibrillin-1HumansHypothalamusMaleMiceMice, Inbred C57BLMice, TransgenicMicrofilament ProteinsNeuronsAdipokinesAppetite DepressantsFBN1 protein, humanFibrillin-1Microfilament ProteinsPeptide FragmentsPeptide Hormones
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.