Evidence map›Paper›PMID 29106390›Full record

ArticleOncogene2018

Glycolysis gatekeeper PDK1 reprograms breast cancer stem cells under hypoxia.

F Peng, J-H Wang, W-J Fan, Y-T Meng, M-M Li, T-T Li, B Cui, H-F Wang, Y Zhao, F An and 11 more

Erratum issuedOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncogene, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 168 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
168citing papers in PubMed, 1 pooled it
7.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

168 citing papers in PubMed, 1 synthesis or guideline pooled it, 318 citations in OpenAlex.

  1. Pooled it
  2. The Dynamic Alliance of p53 and Metabolism in the Tumor Microenvironment Shapes Tumor Evolution.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026
    Review
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  4. TruncatingbioRxiv : the preprint server for biology · 2026
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108 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

21 authors at 7 institutions in 2 countries.

F PengInstitute of Cancer Stem Cell, Dalian Medical University, Dalian, China.
J-H WangDepartment of Oncology, The First Affiliated Hospital of Dalian Medical University, Dalian, China.
W-J FanInstitute of Cancer Stem Cell, Dalian Medical University, Dalian, China.
Y-T MengInstitute of Cancer Stem Cell, Dalian Medical University, Dalian, China.
M-M LiInstitute of Cancer Stem Cell, Dalian Medical University, Dalian, China.
T-T LiInstitute of Cancer Stem Cell, Dalian Medical University, Dalian, China.
B CuiInstitute of Cancer Stem Cell, Dalian Medical University, Dalian, China.
H-F WangInstitute of Cancer Stem Cell, Dalian Medical University, Dalian, China.
Y ZhaoDepartment of Oncology, The First Affiliated Hospital of Dalian Medical University, Dalian, China.
F AnInstitute of Cancer Stem Cell, Dalian Medical University, Dalian, China.
T GuoDepartment of Thoracic Surgery, The First Affiliated Hospital of Dalian Medical University, Dalian, China.
X-F LiuInstitute of Cancer Stem Cell, Dalian Medical University, Dalian, China.
L ZhangInstitute of Cancer Stem Cell, Dalian Medical University, Dalian, China.
L LvDepartment of Pathology, The Second Affiliated Hospital of Dalian Medical University, Dalian, China.
D-K LvInstitute of Cancer Stem Cell, Dalian Medical University, Dalian, China.
L-Z XuInstitute of Cancer Stem Cell, Dalian Medical University, Dalian, China.
J-J XieInstitute of Cancer Stem Cell, Dalian Medical University, Dalian, China.
W-X LinDalian Maternal and Child Care Service Centre, Dalian, Liaoning, China.
E W-F LamDepartment of Surgery and Cancer, Imperial College London, London, UK.
J XuInstitute of Cancer Stem Cell, Dalian Medical University, Dalian, China.
Q LiuInstitute of Cancer Stem Cell, Dalian Medical University, Dalian, China.
Dalian Medical University · CNSun Yat-sen University Cancer Center · CNSun Yat-sen University · CNDalian Maternal and Child Health Hospital · CNFirst Affiliated Hospital of Dalian Medical University · CNImperial College London · GBSecond Affiliated Hospital of Dalian Medical University · CN

Funding

Cancer Research UK 12011
6 · The paper itself

Abstract

Glycolysis is critical for cancer stem cell reprogramming; however, the underlying regulatory mechanisms remain elusive. Here, we show that pyruvate dehydrogenase kinase 1 (PDK1) is enriched in breast cancer stem cells (BCSCs), whereas depletion of PDK1 remarkably diminishes ALDH

Indexed as

Gene Expression Regulation, NeoplasticAnimalsApoptosisBiomarkers, TumorBreast NeoplasmsCell ProliferationFemaleGlycolysisHumansHypoxiaHypoxia-Inducible Factor 1, alpha SubunitMiceMice, Inbred BALB CMice, NudeNeoplastic Stem CellsPrognosisBiomarkers, TumorH19 long non-coding RNAHIF1A protein, humanHypoxia-Inducible Factor 1, alpha SubunitPDK1 protein, humanPdk1 protein, mouseProtein Serine-Threonine KinasesPyruvate Dehydrogenase Acetyl-Transferring KinaseRNA, Long Noncoding

Identifiers

PMID29106390
PMCPMC5851116
OpenAlexW2767996518

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.