ArticlePhysics in medicine and biology2017
PDT dose dosimetry for Photofrin-mediated pleural photodynamic therapy (pPDT).
Article in Physics in medicine and biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Monte Carlo modeling and phantom studies show Cherenkov emission per unit dose during total skin electron therapy is a function of tissue optical properties.Medical physics · 2026Article
- AAPM Task Group Report 274: Fluence rate dosimetry for photodynamic therapy (PDT).Medical physics · 2025Review
- Devices and Methods for Dosimetry of Personalized Photodynamic Therapy of Tumors: A Review on Recent Trends.Cancers · 2024Review
- Clinical PDT dose dosimetry for pleural Photofrin-mediated photodynamic therapy.Journal of biomedical optics · 2024Article
- Fractionated Photofrin-Mediated Photodynamic Therapy Significantly Improves Long-Term Survival.Cancers · 2023Article
- Photocaged Histone Deacetylase Inhibitors as Prodrugs in Targeted Cancer Therapy.Pharmaceuticals (Basel, Switzerland) · 2023Article
- Effects of patient-specific treatment planning on eligibility for photodynamic therapy of deep tissue abscess cavities: retrospective Monte Carlo simulation study.Journal of biomedical optics · 2022Article
- Photodynamic therapy in a pleural cavity using monte carlo simulations with 2D/3D Graphical Visualization.Global journal of cancer therapy · 2022Article
- Photodynamic Treatments for Disseminated Cancer Metastases Using Fiber-Optic Technologies.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Fluorescence and diffuse reflectance provide similar accuracy in recovering fluorophore concentration at short source-detector separations.Journal of modern optics · 2022Article
- Optical property recovery with spatially-resolved diffuse reflectance at short source-detector separations using a compact fiber-optic probe.Biomedical optics express · 2021Article
- Perspectives on interstitial photodynamic therapy for malignant tumors.Journal of biomedical optics · 2021Article
- Determination of the distribution of drug concentration and tissue optical properties for ALA-mediated anal photodynamic therapy.Proceedings of SPIE--the International Society for Optical Engineering · 2021Article
- Estimation of fluorescence probing depth dependence on the distance between source and detector using Monte Carlo modeling.Proceedings of SPIE--the International Society for Optical Engineering · 2021Article
- Light Fluence Rate and Tissue Oxygenation (SPhotochemistry and photobiology · 2020Article
- Reactive Oxygen Species Explicit Dosimetry for Photofrin-mediated Pleural Photodynamic Therapy.Photochemistry and photobiology · 2020Article
- In vivo Spectroscopic Evaluation of the Intraperitoneal Cavity in Canines.Photochemistry and photobiology · 2020Article
- Optimized Cylindrical Diffuser Powers for Interstitial PDT Breast Cancer Treatment Planning: A Simulation Study.BioMed research international · 2020Article
- Monte Carlo investigation of the effect of skin tissue optical properties on detected Cherenkov emission.Proceedings of SPIE--the International Society for Optical Engineering · 2019Article
- Validation of tissue optical properties measurement using diffuse reflectance spectroscopy (DRS).Proceedings of SPIE--the International Society for Optical Engineering · 2019Article
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Authors and funding
8 authors.
Funding
Abstract
Photosensitizer fluorescence excited by photodynamic therapy (PDT) treatment light can be used to monitor the in vivo concentration of the photosensitizer and its photobleaching. The temporal integral of the product of in vivo photosensitizer concentration and light fluence is called PDT dose, which is an important dosimetry quantity for PDT. However, the detected photosensitizer fluorescence may be distorted by variations in the absorption and scattering of both excitation and fluorescence light in tissue. Therefore, correction of the measured fluorescence for distortion due to variable optical properties is required for absolute quantification of photosensitizer concentration. In this study, we have developed a four-channel PDT dose dosimetry system to simultaneously acquire light dosimetry and photosensitizer fluorescence data. We measured PDT dose at four sites in the pleural cavity during pleural PDT. We have determined an empirical optical property correction function using Monte Carlo simulations of fluorescence for a range of physiologically relevant tissue optical properties. Parameters of the optical property correction function for Photofrin fluorescence were determined experimentally using tissue-simulating phantoms. In vivo measurements of photosensitizer fluorescence showed negligible photobleaching of Photofrin during the PDT treatment, but large intra- and inter-patient heterogeneities of in vivo Photofrin concentration are observed. PDT doses delivered to 22 sites in the pleural cavity of 8 patients were different by 2.9 times intra-patient and 8.3 times inter-patient.
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