Evidence map›Paper›PMID 29106325›Full record

ArticleMicrobial drug resistance (Larchmont, N.Y.)2017

Diarrheagenic Escherichia coli and Shigella with High Rate of Extended-Spectrum Beta-Lactamase Production: Two Predominant Etiological Agents of Acute Diarrhea in Shiraz, Iran.

Maneli Aminshahidi, Amir Arastehfar, Gholamreza Pouladfar, Esmayil Arman, Fereshteh Fani

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbial drug resistance (Larchmont, N.Y.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 8 pooled it
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 8 syntheses or guidelines pooled it, 45 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. The increasing antimicrobial resistance ofPathogens and global health · 2023
    Pooled it
  5. Pooled it
  6. Pooled it
  7. Prevalence of fluoroquinolone-resistantPathogens and global health · 2020
    Pooled it
  8. Pooled it
  9. New microbes and new infections · 2026
    Review
  10. Article
  11. Article
  12. Prevalence of CTX-M types among ESBL-producing pathogenicFood science and biotechnology · 2024
    Article
  13. Article
  14. Article
  15. A Systematic Review ofLife (Basel, Switzerland) · 2023
    Review
  16. Characterization of anPathogens (Basel, Switzerland) · 2023
    Article
  17. Article
  18. Review
  19. Prevalence of Multidrug-Resistant DiarrheagenicAntibiotics (Basel, Switzerland) · 2022
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Maneli AminshahidiProfessor Alborzi Clinical Microbiology Research Center, Shiraz University of Medical Sciences , Shiraz, Iran .
Amir ArastehfarProfessor Alborzi Clinical Microbiology Research Center, Shiraz University of Medical Sciences , Shiraz, Iran .
Gholamreza PouladfarProfessor Alborzi Clinical Microbiology Research Center, Shiraz University of Medical Sciences , Shiraz, Iran .
Esmayil ArmanProfessor Alborzi Clinical Microbiology Research Center, Shiraz University of Medical Sciences , Shiraz, Iran .
Fereshteh FaniProfessor Alborzi Clinical Microbiology Research Center, Shiraz University of Medical Sciences , Shiraz, Iran .
Shiraz University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study was conducted to find the etiology of acute diarrhea in Iranian children and determine the antimicrobial resistance patterns. The pathogenic bacteria were recovered from 110/269 (40.9%) diarrheal fecal samples with the following profiles: the most predominant pathogen was diarrheagenic Escherichia coli (DEC) (43.6%), comprising enteroaggregative E. coli (23.6%), enteropathogenic E. coli (10.9%), enteroinvasive E. coli (5.5%), and enterotoxigenic E. coli (3.6%); Shigella spp. (37.3%), Salmonella spp. (12.7%) and Campylobacter jejuni (6.4%) were ranked second and fourth in terms of prevalence, respectively. The rates of extended-spectrum beta-lactamase (ESBL) production were 66.7% and 53.7% in DEC and Shigella, respectively. Resistance to ampicillin (AMP) (95.1%), trimethoprim/sulfamethoxazole (SXT) (73.2%), azithromycin (ATH) (21.9%), and ciprofloxacin (CIP) (14.6%) was observed among Shigella isolates. Multidrug resistance phenotype was observed in 24.4% (10/41) of Shigella isolates, with the most common pattern of resistance to cefotaxime, ceftriaxone, ceftazidime, AMP, SXT, and ATH. This study indicates an alarming increase in the ESBL production of DEC and Shigella spp. and identifies them as the two most prevalent diarrhea-causing enteropathogens in the region. The results show that CIP could be an alternative to third-generation cephalosporins against these two pathogens. Therefore, it is proposed that further investigation be done in the pursuit of alternative antibiotics that are effective against the resistant cases. For instance, one study could look into the comparative clinical effectiveness of third-generation cephalosporins versus CIP, the latter not being presently the drug of choice for the treatment of acute diarrhea in children in Iran.

Indexed as

AdolescentAnti-Bacterial Agentsbeta-LactamasesChildCross-Sectional StudiesDiarrheaEscherichia coliFecesFemaleHumansIranMaleMicrobial Sensitivity TestsPrevalenceShigellaAnti-Bacterial Agentsbeta-Lactamasesacute diarrheadiarrheagenic E. colienteropathogenic bacteriaESBLMDRShigella

Identifiers

PMID29106325
PMCPMC5709696
OpenAlexW2767369842

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.