Evidence map›Paper›PMID 29106309›Full record

ArticleEpigenomics2017

Maternal gestational weight gain and DNA methylation in young women: application of life course mediation methods.

Jonathan Y Huang, David S Siscovick, Hagit Hochner, Yechiel Friedlander, Daniel A Enquobahrie

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epigenomics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 7 citations in OpenAlex.

  1. Effects of DNA methylation on cardiometabolic risk factors: a systematic review and meta-analysis.Archives of public health = Archives belges de sante publique · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 3 countries.

Jonathan Y HuangDepartment of Epidemiology, University of Washington, Seattle, WA, USA.
David S SiscovickNew York Academy of Medicine, New York, NY, USA.
Hagit HochnerBraun School of Public Health, Hebrew University-Hadassah Medical Center, Jerusalem, Israel.
Yechiel FriedlanderBraun School of Public Health, Hebrew University-Hadassah Medical Center, Jerusalem, Israel.
Daniel A EnquobahrieDepartment of Epidemiology, University of Washington, Seattle, WA, USA.
Hadassah Medical Center · ILGTx (United States) · USNew York Academy of Medicine · USUniversity of Washington · US

Funding

University of Washington Reproductive, Perinatal and Pediatric Epidemiology T32HD052462 · NICHD · UNIVERSITY OF WASHINGTON · PI HOLT, VICTORIA L · 2006 to 2017
$2.7M
Maternal Obesity, Fetal Genomics, and Atherosclerotic Metabolic RiskR01HL088884 · NHLBI · UNIVERSITY OF WASHINGTON · PI SISCOVICK, DAVID STUART · 2006 to 2009
$1.7M
Vitamin D related genes and developmental origins of cardiometabolic riskK01HL103174 · NHLBI · UNIVERSITY OF WASHINGTON · PI ENQUOBAHRIE, DANIEL ASMAMAW · 2010 to 2014
$661k
NHLBI NIH HHS K01 HL103174NHLBI NIH HHS R01 HL088884NICHD NIH HHS T32 HD052462
6 · The paper itself

Abstract

aimTo investigate the role of maternal gestational weight gain (GWG) and prepregnancy BMI on programming offspring DNA methylation.

methodsAmong 589 adult (age = 32) women participants of the Jerusalem Perinatal Study, we quantified DNA methylation in five candidate genes. We used inverse probability-weighting and parametric g-formula to estimate direct effects of maternal prepregnancy BMI and GWG on methylation.

resultsHigher maternal GWG, but not prepregnancy BMI, was inversely related to offspring ABCA1 methylation (β = -1.1% per quartile; 95% CI: -2.0, -0.3) after accounting for ancestry, parental and offspring exposures. Total and controlled direct effects were nearly identical suggesting included offspring exposures did not mediate this relationship. Results were robust to sensitivity analyses for missing data and model specification.

conclusionWe find some support for epigenetic programming and highlight strengths and limitations of these methods relative to other prevailing approaches.

Indexed as

DNA MethylationEpigenesis, GeneticAdultATP Binding Cassette Transporter 1Case-Control StudiesFemaleHumansOverweightPregnancyPrenatal Exposure Delayed EffectsWeight GainABCA1 protein, humanATP Binding Cassette Transporter 1ABCA1candidate geneDNA methylationDOHaDgestational weight gainintermediate confoundingmarginal structural modelparametric g-formula

Identifiers

PMID29106309
PMCPMC5704089
OpenAlexW2767600213

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.