Evidence map›Paper›PMID 29105977›Full record

ArticleHuman brain mapping2018

Tau PET imaging predicts cognition in atypical variants of Alzheimer's disease.

Jeffrey S Phillips, Sandhitsu R Das, Corey T McMillan, David J Irwin, Emily E Roll, Fulvio Da Re, Ilya M Nasrallah, David A Wolk, Murray Grossman

Abstract read
In one paragraph

Article in Human brain mapping, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 69 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. AβJournal of Alzheimer's disease : JAD · 2025
    Article
  7. Heterogeneous tau deposition patterns in the preclinical stage link to domain-specific cognitive deficits.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  8. Article
  9. Article
  10. Baseline multimodal imaging to predict longitudinal clinical decline in atypical Alzheimer's disease.Cortex; a journal devoted to the study of the nervous system and behavior · 2024
    Article
  11. medRxiv : the preprint server for health sciences · 2024
    Article
  12. Article
  13. Review
  14. Article
  15. Tau: a biomarker of Huntington's disease.Molecular psychiatry · 2023
    Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Jeffrey S PhillipsPenn Frontotemporal Degeneration Center, Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, 19104.ORCID 0000-0003-0079-9441
Sandhitsu R DasPenn Image Computing and Science Laboratory, University of Pennsylvania, Philadelphia, Pennsylvania, 19104.
Corey T McMillanPenn Frontotemporal Degeneration Center, Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, 19104.ORCID 0000-0002-7581-6405
David J IrwinPenn Frontotemporal Degeneration Center, Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, 19104.
Emily E RollPenn Frontotemporal Degeneration Center, Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, 19104.
Fulvio Da RePenn Frontotemporal Degeneration Center, Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, 19104.ORCID 0000-0003-2288-230X
Ilya M NasrallahDepartment of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, 19104.
David A WolkPenn Memory Center, Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, 19104.
Murray GrossmanPenn Frontotemporal Degeneration Center, Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, 19104.
University of Pennsylvania · USPenn Center for AIDS Research · USUniversity of Milano-Bicocca · IT

Funding

Transgenic Mouse Models of Tau PathologiesP01AG017586 · NIA · UNIVERSITY OF PENNSYLVANIA · PI LEE, VIRGINIA M · 2000 to 2021
$37.3M
UPenn ADCC Biomarker CoreP30AG010124 · NIA · UNIVERSITY OF PENNSYLVANIA · PI XIE, SHARON XIANGWEN · 1991 to 2020
$35.1M
Identification of Endophenotypes in the Behavioral-Variant of Frontotemporal DemeK23NS088341 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI IRWIN, DAVID JOHN · 2014 to 2018
$836k
Multimodal Biomarkers in Frontotemporal Lobar DegenerationK01AG043503 · NIA · UNIVERSITY OF PENNSYLVANIA · PI MCMILLAN, COREY T · 2013 to 2017
$642k
NIA NIH HHS K01 AG043503NIA NIH HHS L30 AG054383NIA NIH HHS P01 AG017586NIA NIH HHS P30 AG010124NINDS NIH HHS K23 NS088341
6 · The paper itself

Abstract

Accumulation of paired helical filament tau contributes to neurodegeneration in Alzheimer's disease (AD).

Indexed as

CarbolinesCognitionRadiopharmaceuticalsAgedAlzheimer DiseaseAmnesiaAphasia, Primary ProgressiveAtrophyBrainCohort StudiesFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedNeuropsychological Tests7-(6-fluoropyridin-3-yl)-5H-pyrido(4,3-b)indoleCarbolinesMAPT protein, humanRadiopharmaceuticalstau ProteinsAlzheimer diseasecognitiondementialanguagememoryneurofibrillary tanglespositron emission tomographyposterior cortical atrophyprimary progressive aphasiaTau

Identifiers

PMID29105977
PMCPMC5764792
OpenAlexW2767753502

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.