ArticleHuman brain mapping2018
Altered structure and functional connection in patients with classical trigeminal neuralgia.
Article in Human brain mapping, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 2 of them syntheses that pooled it.
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Who cites it
60 citing papers in PubMed, 2 syntheses or guidelines pooled it, 99 citations in OpenAlex.
- Pooled it
- A meta-analytic study of experimental and chronic orofacial pain excluding headache disorders.NeuroImage. Clinical · 2018Pooled it
- Brain Regional Predictors of Surgical Response Are Dynamically Associated with Post-Surgical Pain Relief in Trigeminal Neuralgia.Brain sciences · 2026Article
- Exploratory development of prediction models for pharmacotherapy outcomes in trigeminal neuralgia: a combined analysis based on multi-source data.The journal of headache and pain · 2026Article
- Abnormal Regional Brain Functional Activity and Brain Network Connectivity in Primary Trigeminal Neuralgia Patients: An Activation Likelihood Estimation Meta-Analysis Based on Resting-State fMRI.Journal of pain research · 2026Review
- Cerebellar neurocan gene expression is a common pathogenic factor of trigeminal neuralgia and depression.The journal of headache and pain · 2025Article
- L3MBTL2 as a novel therapeutic target for trigeminal neuralgia: evidence from integrated TWAS, multi-tissue MR, and experimental validation.The journal of headache and pain · 2025Article
- Reduced volume in the amygdala of trigeminal neuralgia patients: a neuroimaging study with clinical correlates.Experimental brain research · 2025Article
- Gray matter alterations and pain-related emotional processing in patients with adenomyosis-associated dysmenorrhea: a neuroimaging perspective.Quantitative imaging in medicine and surgery · 2025Article
- Article
- Disruption of functional and structural topological organization in specific subnetwork among patients with classical trigeminal neuralgia: a graph theory-based magnetic resonance imaging study.Brain imaging and behavior · 2025Article
- Network control theory uncovers aberrant connectome controllability in trigeminal neuralgia.The journal of headache and pain · 2025Article
- Structural alterations in occipital cortices in trigeminal neuralgia: a voxel- and surface-based morphometric MRI study.The journal of headache and pain · 2025Article
- Effect of electroacupuncture on anxiety in patients with obesity: a protocol for a randomised, blinded, sham-controlled trial.BMJ open · 2025Article
- Aberrant static and dynamic functional connectivity of insular cortex in patients with trigeminal neuralgia.Scientific reports · 2025Article
- Thalamic changes in patients with chronic facial pain.Neuroradiology · 2025Article
- A study of brain function changes in patients with trigeminal neuralgia of different laterality based on rs-fMRI.Journal of oral & facial pain and headache · 2025Article
- Cognitive Decline in Patients With Trigeminal Neuralgia: A Resting-State fMRI Study.Brain and behavior · 2025Article
- Graph theory-driven structural and functional connectivity analyses revealing regulatory mechanisms of brain network in patients with classic trigeminal neuralgia.Brain imaging and behavior · 2025Article
- Amplitude of low-frequency fluctuations in classical trigeminal neuralgia patients with purely paroxysmal and concomitant continuous pain.Frontiers in pain research (Lausanne, Switzerland) · 2025Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Classical trigeminal neuralgia (TN) is a specific type of neuropathic orofacial pain of which the plasticity of brain structure and connectivity have remained largely unknown. A total of 62 TN patients were included and referred to MRI scans. Voxel-based morphometry was used to analyze the change of gray matter volume. Resting-state functional imaging was used to analyze the connectivity between brain regions. The results showed gray matter volume reduction in components of the prefrontal cortex, precentral gyrus, cerebellar tonsil, thalamus, hypothalamus, and nucleus accumbens among right TN patient and in the inferior frontal gyrus, precentral gyrus, cerebellum, thalamus, ventral striatum, and putamen among left TN patients. The connections between the right superior frontal gyrus and right middle frontal gyrus were lower in right TN patients. The connection between the left precentral gyrus and the left superior frontal gyrus was lower while the connection between bilateral thalamus was higher in left TN patients. The changes of volume in bilateral thalamus of right TN patients and left ventral striatum of left TN patients, and the connectivity between bilateral thalamus of left TN patients were moderately correlated with pain duration. These findings suggest that brain regions such as the thalamus may not only be involved in processing of pain stimuli but also be important for the development of TN. The left hemisphere may be dominant in processing and modulation of TN pain signal. Chronification of TN induces volume changes in brain regions which are associated with emotional or cognitive modulation of pain. Hum Brain Mapp 39:609-621, 2018. © 2017 Wiley Periodicals, Inc.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.