Evidence map›Paper›PMID 29105657›Full record

ArticleSpinal cord2018

Gait training after spinal cord injury: safety, feasibility and gait function following 8 weeks of training with the exoskeletons from Ekso Bionics.

Carsten Bach Baunsgaard, Ulla Vig Nissen, Anne Katrin Brust, Angela Frotzler, Cornelia Ribeill, Yorck-Bernhard Kalke, Natacha León, Belén Gómez, Kersti Samuelsson, Wolfram Antepohl and 9 more

Registry-linked trialOpen access · bronzeAbstract read
PubMed Publisher
In one paragraph

Article in Spinal cord, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04221373 (The Effects of Incorporated Exoskeletal-Assisted Walking in Spinal Cord Injury), which is not on this map. Cited by 77 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
77citing papers in PubMed, 8 pooled it
6.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04221373 nacompletednot on this mapstarted 2019, after this paper: background citation

The Effects of Incorporated Exoskeletal-Assisted Walking in Spinal Cord Injury (SCI) Acute Inpatient Rehabilitation

TypeinterventionalSponsorIcahn School of Medicine at Mount SinaiRan2019 to 2022Enrolled32ConditionsSpinal Cord Injuries, InpatientArmsEkso™ powered exoskeleton, Standard of care
3 · Its place in the literature

Who cites it

77 citing papers in PubMed, 8 syntheses or guidelines pooled it, 177 citations in OpenAlex.

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17 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 7 institutions in 6 countries.

Carsten Bach BaunsgaardClinic for Spinal Cord Injuries, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. cb.baunsgaard@gmail.com.ORCID http://orcid.org/0000-0002-6172-1835
Ulla Vig NissenClinic for Spinal Cord Injuries, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Anne Katrin BrustSwiss Paraplegic Centre (SPC), Nottwil, Switzerland.
Angela FrotzlerSwiss Paraplegic Centre (SPC), Nottwil, Switzerland.
Cornelia RibeillSCI Centre Orthopaedic Department Ulm University, Ulm, Germany.
Yorck-Bernhard KalkeSCI Centre Orthopaedic Department Ulm University, Ulm, Germany.
Natacha LeónFundación Lesionado Medular (FLM), Madrid, Spain.
Belén GómezFundación Lesionado Medular (FLM), Madrid, Spain.
Kersti SamuelssonDepartment of Rehabilitation Medicine and Department of Medical and Health Sciences, Linköping University, Linköping, Sweden.
Wolfram AntepohlDepartment of Rehabilitation Medicine and Department of Medical and Health Sciences, Linköping University, Linköping, Sweden.
Ulrika HolmströmSpinal Cord Rehabilitation Unit, Uppsala University Hospital, Uppsala, Sweden.
Niklas MarklundSpinal Cord Rehabilitation Unit, Uppsala University Hospital, Uppsala, Sweden.ORCID http://orcid.org/0000-0002-9797-5626
Thomas GlottSunnaas Rehabilitation Hospital, Nesoddtangen, Norway.
Arve OpheimSunnaas Rehabilitation Hospital, Nesoddtangen, Norway.
Jesus BenitoInstitute Guttmann, Neurorehabilitation Hospital, Barcelona, Spain.
Narda MurilloInstitute Guttmann, Neurorehabilitation Hospital, Barcelona, Spain.
Janneke NachtegaalHeliomare Rehabilitation Center, Wijk aan Zee, The Netherlands.
Willemijn FaberHeliomare Rehabilitation Center, Wijk aan Zee, The Netherlands.
Fin Biering-SørensenClinic for Spinal Cord Injuries, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
University of Copenhagen · DKHeliomare · NLInstitut Guttmann · ESLinköping University · SESunnaas sykehus · NOSwiss Paraplegic Center · CHUppsala University Hospital · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

STUDY

designProspective quasi-experimental study, pre- and post-design.

objectivesAssess safety, feasibility, training characteristics and changes in gait function for persons with spinal cord injury (SCI) using the robotic exoskeletons from Ekso Bionics.

settingNine European rehabilitation centres.

methodsRobotic exoskeleton gait training, three times weekly over 8 weeks. Time upright, time walking and steps in the device (training characteristics) were recorded longitudinally. Gait and neurological function were measured by 10 Metre Walk Test (10 MWT), Timed Up and Go (TUG), Berg Balance Scale (BBS), Walking Index for Spinal Cord Injury (WISCI) II and Lower Extremity Motor Score (LEMS).

resultsFifty-two participants completed the training protocol. Median age: 35.8 years (IQR 27.5-52.5), men/women: N = 36/16, neurological level of injury: C1-L2 and severity: AIS A-D (American Spinal Injury Association Impairment Scale). Time since injury (TSI) < 1 year, N = 25; > 1 year, N = 27. No serious adverse events occurred. Three participants dropped out following ankle swelling (overuse injury). Four participants sustained a Category II pressure ulcer at contact points with the device but completed the study and skin normalized. Training characteristics increased significantly for all subgroups. The number of participants with TSI < 1 year and gait function increased from 20 to 56% (P = 0.004) and 10MWT, TUG, BBS and LEMS results improved (P < 0.05). The number of participants with TSI > 1 year and gait function, increased from 41 to 44% and TUG and BBS results improved (P < 0.05).

conclusionsExoskeleton training was generally safe and feasible in a heterogeneous sample of persons with SCI. Results indicate potential benefits on gait function and balance.

Indexed as

Exoskeleton DeviceAdolescentAdultAgedBionicsExercise TherapyFemaleGaitHumansMaleMiddle AgedProspective StudiesSpinal Cord InjuriesTreatment OutcomeYoung Adult

Identifiers

PMID29105657
OpenAlexW2766635141

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.