Evidence map›Paper›PMID 29105512›Full record

ArticleExperimental biology and medicine (Maywood, N.J.)2018

Changes in the metabolome and microRNA levels in biological fluids might represent biomarkers of neurotoxicity: A trimethyltin study.

Syed Z Imam, Zhen He, Elvis Cuevas, Hector Rosas-Hernandez, Susan M Lantz, Sumit Sarkar, James Raymick, Bonnie Robinson, Joseph P Hanig, David Herr and 17 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental biology and medicine (Maywood, N.J.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Profiling Secreted miRNA Biomarkers of Chemical-Induced Neurodegeneration in Human iPSC-Derived Neurons.Toxicological sciences : an official journal of the Society of Toxicology · 2022
    Article
  5. Blood Neurofilament Light Chain as a Potential Biomarker for Central and Peripheral Nervous Toxicity in Rats.Toxicological sciences : an official journal of the Society of Toxicology · 2021
    Article
  6. Article
  7. Drug discovery and development: Biomarkers of neurotoxicity and neurodegeneration.Experimental biology and medicine (Maywood, N.J.) · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors at 9 institutions in 2 countries.

Syed Z Imam1 Division of Neurotoxicology, US FDA, 4136 NCTR , Jefferson, AR 72079, USA.
Zhen He1 Division of Neurotoxicology, US FDA, 4136 NCTR , Jefferson, AR 72079, USA.
Elvis Cuevas1 Division of Neurotoxicology, US FDA, 4136 NCTR , Jefferson, AR 72079, USA.
Hector Rosas-Hernandez1 Division of Neurotoxicology, US FDA, 4136 NCTR , Jefferson, AR 72079, USA.
Susan M Lantz1 Division of Neurotoxicology, US FDA, 4136 NCTR , Jefferson, AR 72079, USA.
Sumit Sarkar1 Division of Neurotoxicology, US FDA, 4136 NCTR , Jefferson, AR 72079, USA.
James Raymick1 Division of Neurotoxicology, US FDA, 4136 NCTR , Jefferson, AR 72079, USA.
Bonnie Robinson1 Division of Neurotoxicology, US FDA, 4136 NCTR , Jefferson, AR 72079, USA.ORCID 0000-0003-0805-8138
Joseph P Hanig2 US FDA 117009 CDER , MD 20993, USA.
David Herr3 US EPA, 96653 NHEERL , Research Triangle Park, North Carolina, NC 27711, USA.ORCID 0000-0002-5326-2544
Denise MacMillan3 US EPA, 96653 NHEERL , Research Triangle Park, North Carolina, NC 27711, USA.
Aaron Smith4 Lilly, Lilly Corporate Center, Indianapolis, Indiana, IN 46285, USA.
Serguei Liachenko1 Division of Neurotoxicology, US FDA, 4136 NCTR , Jefferson, AR 72079, USA.
Sherry Ferguson1 Division of Neurotoxicology, US FDA, 4136 NCTR , Jefferson, AR 72079, USA.
James O'Callaghan5 CDC-NIOSH, Morgantown, WV 26505-2888, USA.
Diane Miller5 CDC-NIOSH, Morgantown, WV 26505-2888, USA.
Christopher Somps6 105623 Pfizer , Groton, Connecticut, CT 06340, USA.
Ingrid D Pardo6 105623 Pfizer , Groton, Connecticut, CT 06340, USA.
William Slikker1 Division of Neurotoxicology, US FDA, 4136 NCTR , Jefferson, AR 72079, USA.
Jennifer B Pierson7 ILSI-HESI, Washington, DC 20005, USA.
Ruth Roberts8 Department of Biosciences, University of Birmingham, Birmingham B15 2TT, UK.
Binsheng Gong9 Division of Bioinformatics, US FDA, 4136 NCTR , Jefferson, AR 72079, USA.
Weida Tong9 Division of Bioinformatics, US FDA, 4136 NCTR , Jefferson, AR 72079, USA.
Michael Aschner10 Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Mary J Kallman11 Kallman Preclinical Consulting, Greenfield, IN 46140, USA.
David Calligaro3 US EPA, 96653 NHEERL , Research Triangle Park, North Carolina, NC 27711, USA.
Merle G Paule1 Division of Neurotoxicology, US FDA, 4136 NCTR , Jefferson, AR 72079, USA.
National Center for Toxicological Research · USEnvironmental Protection Agency · USNational Institute for Occupational Safety and Health · USPfizer (United States) · USAlbert Einstein College of Medicine · USEli Lilly (United States) · USHealth and Environmental Sciences Institute · USUnited States Food and Drug Administration · USUniversity of Birmingham · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neurotoxicity has been linked with exposure to a number of common drugs and chemicals, yet efficient, accurate, and minimally invasive methods to detect it are lacking. Fluid-based biomarkers such as those found in serum, plasma, urine, and cerebrospinal fluid have great potential due to the relative ease of sampling but at present, data on their expression and translation are lacking or inconsistent. In this pilot study using a trimethyl tin rat model of central nervous system toxicity, we have applied state-of-the-art assessment techniques to identify potential individual biomarkers and patterns of biomarkers in serum, plasma, urine or cerebral spinal fluid that may be indicative of nerve cell damage and degeneration. Overall changes in metabolites and microRNAs were observed in biological fluids that were associated with neurotoxic damage induced by trimethyl tin. Behavioral changes and magnetic resonance imaging T

Indexed as

BiomarkersAmino AcidsAnimalsBehavior, AnimalBody FluidsCentral Nervous SystemHumansMagnetic Resonance ImagingMaleMetabolomeMicroRNAsNeuronsNeurotoxicity SyndromesPilot ProjectsRatsRats, Sprague-DawleyAmino AcidsBiomarkersMicroRNAstrimethyltinTrimethyltin CompoundsBioimagingbiomarkersbrainneurobiologyneurotoxicologytranslational

Identifiers

PMID29105512
PMCPMC5813866
OpenAlexW2767732149

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.