Evidence map›Paper›PMID 29105346›Full record

ReviewInternational journal of rheumatic diseases2018

Is Kawasaki disease an infectious disorder?

Anne H Rowley

Open access · greenAbstract readReview
In one paragraph

Review in International journal of rheumatic diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed, 2 pooled it
8.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 2 syntheses or guidelines pooled it, 114 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Gut Microbiota Alterations in Patients With Kawasaki Disease.Arteriosclerosis, thrombosis, and vascular biology · 2025
    Review
  14. Article
  15. Observational
  16. Observational
  17. Article
  18. Review
  19. Review
  20. [Characteristics of intestinal microbiota in the acute phase of Kawasaki disease in infants and children].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2024
    Article

4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Anne H RowleyDepartments of Pediatrics and Microbiology/Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Northwestern University · US

Funding

The Pathogenesis of Kawasaki DiseaseR56AI106030 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ROWLEY, ANNE H · 2014 to 2014
$401k
The Vasculitis of Kawasaki DiseaseR21AR068041 · NIAMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ROWLEY, ANNE H · 2015 to 2016
$391k
NIAID NIH HHS R56 AI106030NIAMS NIH HHS R21 AR068041
6 · The paper itself

Abstract

Although the etiology of Kawasaki disease (KD) is largely unknown, a large body of clinical, epidemiologic, immunologic, pathologic and ultrastructural evidence suggests that an infectious agent triggers a cascade that causes the illness. However, this elusive infectious agent remains unidentified at present. Increasingly sensitive molecular methods for identifying microbial nucleic acids and proteins in tissue samples continue to rapidly emerge, and these methods should be utilized in studies on KD etiology as they become available. Identifying the etiology of this enigmatic disease remains the single most important research goal in the field, and accomplishing this goal is the best means to improve diagnosis, treatment and prevention of this potentially fatal childhood disease.

Indexed as

Age of OnsetChild, PreschoolCommunicable DiseasesGenetic Predisposition to DiseaseHumansInfantMucocutaneous Lymph Node SyndromePhenotypePrognosisRisk Factorsacquired immune responsecytotoxic T lymphocytesIgAinterferonoligoclonal antibodies

Identifiers

PMID29105346
PMCPMC5777874
OpenAlexW2765281142

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.