ArticleHuman brain mapping2018
Different shades of default mode disturbance in schizophrenia: Subnodal covariance estimation in structure and function.
Article in Human brain mapping, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
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Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- A meta-analysis and systematic review of single vs. multimodal neuroimaging techniques in the classification of psychosis.Molecular psychiatry · 2023Pooled it
- Structural covariance networks in schizophrenia: A systematic review Part I.Schizophrenia research · 2022Pooled it
- Structural covariance networks in schizophrenia: A systematic review Part II.Schizophrenia research · 2022Pooled it
- Structural covariance network topology in individuals at clinical high risk for psychosis: the ENIGMA-CHR Study.Molecular psychiatry · 2026Article
- Heterogeneity in functional connectivity: Dimensional predictors of individual variability during rest and task fMRI in psychosis.Progress in neuro-psychopharmacology & biological psychiatry · 2024Article
- Dysconnection and cognition in schizophrenia: A spectral dynamic causal modeling study.Human brain mapping · 2023Article
- Widespread Intra- and Inter-Network Dysconnectivity among Large-Scale Resting State Networks in Schizophrenia.Journal of clinical medicine · 2023Article
- Opposite effects of positive and negative symptoms on resting-state brain networks in schizophrenia.Communications biology · 2023Article
- Limbic links to paranoia: increased resting-state functional connectivity between amygdala, hippocampus and orbitofrontal cortex in schizophrenia patients with paranoia.European archives of psychiatry and clinical neuroscience · 2022Article
- Feeding the machine: Challenges to reproducible predictive modeling in resting-state connectomics.Network neuroscience (Cambridge, Mass.) · 2022Article
- Maternal warmth is associated with network segregation across late childhood: A longitudinal neuroimaging study.Frontiers in psychology · 2022Article
- Shared Patterns of Brain Functional Connectivity for the Comorbidity between Migraine and Insomnia.Biomedicines · 2021Article
- Brain functional network modeling and analysis based on fMRI: a systematic review.Cognitive neurodynamics · 2021Review
- Towards understanding neurocognitive mechanisms of parenting: Maternal behaviors and structural brain network organization in late childhood.Human brain mapping · 2021Article
- Without insight accompanied with deteriorated brain functional alterations in healthy individuals with auditory verbal hallucinations: a pilot study.Brain imaging and behavior · 2020Article
- Brain structural covariance networks in obsessive-compulsive disorder: a graph analysis from the ENIGMA Consortium.Brain : a journal of neurology · 2020Article
- Identifying brain network topology changes in task processes and psychiatric disorders.Network neuroscience (Cambridge, Mass.) · 2020Article
- Revisiting correlation-based functional connectivity and its relationship with structural connectivity.Network neuroscience (Cambridge, Mass.) · 2020Article
- Structural Covariance Reveals Alterations in Control and Salience Network Integrity in Chronic Schizophrenia.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- A multicenter study of ketamine effects on functional connectivity: Large scale network relationships, hubs and symptom mechanisms.NeuroImage. Clinical · 2019Article
Corrections and comments
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Authors and funding
12 authors at 9 institutions in 5 countries.
Funding
Abstract
Schizophrenia is a devastating mental disease with an apparent disruption in the highly associative default mode network (DMN). Interplay between this canonical network and others probably contributes to goal-directed behavior so its disturbance is a candidate neural fingerprint underlying schizophrenia psychopathology. Previous research has reported both hyperconnectivity and hypoconnectivity within the DMN, and both increased and decreased DMN coupling with the multimodal saliency network (SN) and dorsal attention network (DAN). This study systematically revisited network disruption in patients with schizophrenia using data-derived network atlases and multivariate pattern-learning algorithms in a multisite dataset (n = 325). Resting-state fluctuations in unconstrained brain states were used to estimate functional connectivity, and local volume differences between individuals were used to estimate structural co-occurrence within and between the DMN, SN, and DAN. In brain structure and function, sparse inverse covariance estimates of network coupling were used to characterize healthy participants and patients with schizophrenia, and to identify statistically significant group differences. Evidence did not confirm that the backbone of the DMN was the primary driver of brain dysfunction in schizophrenia. Instead, functional and structural aberrations were frequently located outside of the DMN core, such as in the anterior temporoparietal junction and precuneus. Additionally, functional covariation analyses highlighted dysfunctional DMN-DAN coupling, while structural covariation results highlighted aberrant DMN-SN coupling. Our findings reframe the role of the DMN core and its relation to canonical networks in schizophrenia. We thus underline the importance of large-scale neural interactions as effective biomarkers and indicators of how to tailor psychiatric care to single patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.