ReviewTraffic (Copenhagen, Denmark)2018
The biology and polymer physics underlying large-scale chromosome organization.
Review in Traffic (Copenhagen, Denmark), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 59 citations in OpenAlex.
- Article
- Nucleosome placement and polymer mechanics explain genomic contacts on 100 kb scales.Nucleic acids research · 2025Article
- Transcription-dependent mobility of single genes and genome-wide motions in live human cells.Nature communications · 2024Article
- Exploring protein-mediated compaction of DNA by coarse-grained simulations and unsupervised learning.Biophysical journal · 2024Article
- Bottom-up data integration in polymer models of chromatin organization.Biophysical journal · 2024Article
- Article
- Appetizer on soft matter physics concepts in mechanobiology.Development, growth & differentiation · 2023Review
- Mesoscale, long-time mixing of chromosomes and its connection to polymer dynamics.PLoS computational biology · 2023Article
- Hypothesis-driven probabilistic modelling enables a principled perspective of genomic compartments.Nucleic acids research · 2023Article
- HiC-GNN: A generalizable model for 3D chromosome reconstruction using graph convolutional neural networks.Computational and structural biotechnology journal · 2023Article
- A Multigraph-Based Representation of Hi-C Data.Genes · 2022Article
- Article
- Circuit topology analysis of cellular genome reveals signature motifs, conformational heterogeneity, and scaling.iScience · 2022Article
- Longer DNA exhibits greater potential for cell-free gene expression.Scientific reports · 2021Article
- Slow chromatin dynamics enhances promoter accessibility to transcriptional condensates.Nucleic acids research · 2021Article
- The Nucleome Data Bank: web-based resources to simulate and analyze the three-dimensional genome.Nucleic acids research · 2021Article
- Article
- A Polymer Model of the Whole Genome.Biophysical journal · 2020Article
- The rich inner life of the cell nucleus: dynamic organization, active flows, and emergent rheology.Biophysical reviews · 2020Review
- A sporadic case of congenital aniridia caused by pericentric inversion inv(11)(p13q14) associated with a 977 kb deletion in the 11p13 region.BMC medical genomics · 2020Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chromosome large-scale organization is a beautiful example of the interplay between physics and biology. DNA molecules are polymers and thus belong to the class of molecules for which physicists have developed models and formulated testable hypotheses to understand their arrangement and dynamic properties in solution, based on the principles of polymer physics. Biologists documented and discovered the biochemical basis for the structure, function and dynamic spatial organization of chromosomes in cells. The underlying principles of chromosome organization have recently been revealed in unprecedented detail using high-resolution chromosome capture technology that can simultaneously detect chromosome contact sites throughout the genome. These independent lines of investigation have now converged on a model in which DNA loops, generated by the loop extrusion mechanism, are the basic organizational and functional units of the chromosome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.