ArticleAlcoholism, clinical and experimental research2018
Cortical Thickness in Adolescents with a Family History of Alcohol Use Disorder.
Article in Alcoholism, clinical and experimental research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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24 citing papers in PubMed, 45 citations in OpenAlex.
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- Cortical Thickness of the Orbitofrontal Cortex in Patients with Alcohol Use Disorder.Brain sciences · 2023Article
- Emotion regulation in young adults with family history of harmful alcohol use: A fMRI study.Drug and alcohol dependence · 2023Article
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- Adolescent alcohol use is linked to disruptions in age-appropriate cortical thinning: an unsupervised machine learning approach.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Epigenetic Effects in HPA Axis Genes Associated with Cortical Thickness, ERP Components and SUD Outcome.Behavioral sciences (Basel, Switzerland) · 2022Article
- Shapes of subcortical structures in adolescents with and without familial history of substance use disorder.Human brain mapping · 2022Article
- Neuroimaging in alcohol use disorder: From mouse to man.Journal of neuroscience research · 2022Review
- The Effects of Alcohol and Cannabis Use on the Cortical Thickness of Cognitive Control and Salience Brain Networks in Emerging Adulthood: A Co-twin Control Study.Biological psychiatry · 2021Article
- Dimensions of Craving Interact withBrain sciences · 2021Article
- Bidirectional causality between addiction and cognitive deficits.International review of neurobiology · 2021Review
- Convergent Evidence for Predispositional Effects of Brain Gray Matter Volume on Alcohol Consumption.Biological psychiatry · 2020Article
- A TMS study of preparatory suppression in binge drinkers.NeuroImage. Clinical · 2020Article
- Alcohol Induced Brain and Liver Damage: Advantages of a Porcine Alcohol Use Disorder Model.Frontiers in physiology · 2020Review
- Sex Differences in the Neurobiology of Alcohol Use Disorder.Alcohol research : current reviews · 2020Review
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6 authors at 1 institution in 1 country.
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Abstract
backgroundIndividuals with a family history (FH+) of alcohol use disorder (AUD) have a higher risk for developing an AUD than those with no family history (FH-) of AUD. In addition, FH+ individuals tend to perform worse on neuropsychological measures and show heightened impulsivity, which may be due to underlying differences in brain structure such as cortical thickness. The primary aim of this study was to investigate differences in cortical thickness in FH+ compared to FH- adolescents. Secondary aims were to (i) investigate differences in executive functioning and impulsivity, and (ii) examine associations between brain structure and behavior.
methodsBrain scans of 95 FH- and 93 FH+ subjects aged 13 to 18 were obtained using magnetic resonance imaging. FH+ subjects were required to have at least 1 biological parent with a history of an AUD. FH+ and FH- individuals had limited or no past alcohol use, thereby minimizing potential effects of alcohol. Subjects were evaluated on impulsivity and executive functioning tasks. Thicknesses of cortical lobes and subregions were analyzed using FreeSurfer. Regions showing group differences were examined for group-by-age interactions and correlations with neuropsychological and personality measures.
resultsFH+ adolescents had thinner cortices in frontal and parietal lobes, notably in the medial orbitofrontal, lateral orbitofrontal, and superior parietal cortices. The difference in cortical thickness between family history groups was strongest among the youngest subjects. FH+ subjects were also more impulsive and had poorer performance on a spatial memory task.
conclusionsThese findings demonstrate frontal and parietal structural differences in FH+ adolescents that might underlie cognitive and behavioral characteristics associated with AUD risk.
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