ReviewVirchows Archiv : an international journal of pathology2018
Metastatic non-small cell lung carcinoma a mimic of primary breast carcinoma-case series and literature review.
Review in Virchows Archiv : an international journal of pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
- Systematic review of lung cancer with breast metastasis.Journal of thoracic disease · 2025Review
- Misdiagnosis of bilateral breast metastases as primary benign tumors secondary to lung large-cell neuroendocrine carcinoma: a case report.Discover oncology · 2025Article
- Breast Mass Revealing Hidden Lung Cancer.Cureus · 2025Article
- Primary lung adenocarcinoma with breast metastasis harboring the EML4‑ALK fusion: A case report.Oncology letters · 2024Article
- Breast metastasis from endometrial clear cell carcinoma: A case report and review of the literature.Frontiers in oncology · 2022Article
- Complex Differential Diagnosis between Primary Breast Cancer and Breast Metastasis from EGFR-Mutated Lung Adenocarcinoma: Case Report and Literature Review.Current oncology (Toronto, Ont.) · 2021Review
- Breast metastases from primary lung cancer: a retrospective case series on clinical, ultrasonographic, and immunohistochemical features.Translational lung cancer research · 2021Article
- Three Cases of Breast Metastases from Lung Cancer and Systematic Review of the Literature.European journal of breast health · 2021Article
- Metastatic adenocarcinoma to the breast from the lung simulates primary breast carcinoma-a clinicopathologic study.Translational cancer research · 2021Article
- Bilateral Breast Metastases from Epstein-Barr Virus-Associated Gastric Cancer during Pregnancy: Is There a Method to Its Madness?Journal of gastric cancer · 2020Article
- Metastases to the Breast from Extramammary Nonhematological Malignancies: Case Series.International journal of general medicine · 2020Article
- Clinical and molecular characteristics of secondary breast metastases from primary lung cancer: a study of 22 Chinese cases.International journal of clinical and experimental pathology · 2020Article
- Breast metastasis from primary lung adenocarcinoma in a young woman: A case report and literature review.World journal of clinical oncology · 2019Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metastatic tumors to the breast are rare but constitute a major diagnostic dilemma. Of these, non-mammary carcinomatous metastases to the breast are particularly challenging and, without a clinical history, may be extremely difficult to distinguish from primary breast carcinoma (PBC). We specifically studied metastatic tumors of pulmonary origin, as the lung is one of the major primary sites for carcinomatous metastasis to breast. Sixteen metastatic lung tumors to the breast were identified in our archives between 1996 and 2017 including 12 non-small cell lung carcinomas (NSCLC), one large-cell neuroendocrine, one atypical carcinoid, and two small-cell carcinomas. Adenocarcinoma was the most frequent amongst the NSCLCs (11/14). We retrieved the clinical information of these cases and reviewed the pathological characteristics to provide practical tools for pathologists to aid in their identification. Even in the absence of a clinical history of lung cancer, metastatic pulmonary adenocarcinoma to the breast should be considered in at least one of the following scenarios: (1) single or multiple well-circumscribed lesions of the breast that lack an in situ component and that are accompanied by distant metastases but negative axillary lymph nodes, (2) breast tumors that are triple negative yet not high-grade, or (3) breast tumors presenting as stage 4 disease and/or having an unusually aggressive clinical course on standard breast therapy. Accurate and timely diagnosis of these tumors is mandatory because of treatment and prognostic implications.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.