ReviewNeurosurgical review2018
Is non-awake surgery for supratentorial adult low-grade glioma treatment still feasible?
Review in Neurosurgical review, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 73 citations in OpenAlex.
- Awake surgery versus general anesthesia in the treatment of Diffuse Low-Grade Gliomas - and the role of supplementary intraoperative techniques: a systematic review and meta-analysis.Journal of neuro-oncology · 2026Pooled it
- Comparison of Clinical Effects of Temozolomide Single Agent and Combined Doxorubicin in the Treatment of Glioma.Journal of healthcare engineering · 2022Trial
- Cognitive Profiles and Determinants of Eligibility for Awake Surgery in Non-Dominant Hemisphere Gliomas: A Narrative Review.Brain and behavior · 2025Review
- The inferior fronto-occipital fasciculus: bridging phylogeny, ontogeny and functional anatomy.Brain : a journal of neurology · 2025Review
- Quantitative evaluation of neuroradiological and morphometric alteration of inferior Fronto-Occipital Fascicle across different brain tumor histotype: an Italian multicentric study.Acta neurochirurgica · 2025Article
- Review
- Mini-strokes after awake surgery for glioma resection: are there anesthesia related factors?Acta neurochirurgica · 2024Article
- Radiological and Not Clinical Variables Guide the Surgical Plan in Patients with Glioblastoma.Current oncology (Toronto, Ont.) · 2024Article
- Performance of intraoperative neurocognitive tests during awake surgery for patients with diffuse low-grade glioma.Neurosurgical review · 2024Observational
- Awake surgery for a deaf patient using sign language: A case report.Surgical neurology international · 2024Article
- Guidelines for Awake Surgery.Neurologia medico-chirurgica · 2024Article
- The state of art of awake craniotomy in Latin American countries: a scoping review.Journal of neuro-oncology · 2023Article
- Editorial: Advances in surgical approaches for the treatment of glioma.Frontiers in oncology · 2023Article
- "Grass Is Always Greener on the Other Side" or Is It?! Comparison of Trend of Awake Craniotomy in Neuro-Oncology and Asleep Deep Brain Stimulation.Stereotactic and functional neurosurgery · 2023Article
- What surgical approach for left-sided eloquent glioblastoma: biopsy, resection under general anesthesia or awake craniotomy?Journal of neuro-oncology · 2022Article
- Large tumour volume reduction of IDH-mutated anaplastic glioma involving the insular region following radiotherapy.BMC neurology · 2022Article
- Intraoperative hand strength as an indicator of consciousness during awake craniotomy: a prospective, observational study.Scientific reports · 2022Observational
- Awake craniotomy with dexmedetomidine during resection of brain tumours located in eloquent regions.Anaesthesiology intensive therapy · 2022Article
- Neurocognitive Outcome and Seizure Freedom After Awake Surgery of Gliomas.Frontiers in oncology · 2022Article
- The Effect of Right Temporal Lobe Gliomas on Left and Right Hemisphere Neural Processing During Speech Perception and Production Tasks.Frontiers in human neuroscience · 2022Article
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this short review, the author performs a database search, summarizes, and discusses studies that provide information on the need to perform awake surgery to preserve quality of life/return to work of adult patients who undergo resection for a supratentorial low-grade glioma (LGG). Based upon the currently available data, the author concludes that in LGG, patients with no or only mild deficits at diagnosis, non-awake surgery can no longer be achieved. Indeed, awake craniotomy with intrasurgical electrical mapping has resulted in an increase of the extent of resection and overall survival in LGG. Furthermore, in order to resume a normal familial, social, and professional life, LGG patients with a prolonged survival expectancy have to benefit not only from language mapping when the tumor involves the left "dominant" hemisphere, but also from intraoperative mapping of sensorimotor, visuospatial, higher cognitive, and emotional functions under local anesthesia, even for gliomas situated within presumed "non-language" areas such as the right "non-dominant" hemisphere. In other words, the ultimate goal is to map the functional connectome for each patient in order to perform the resection up to the eloquent networks and then to optimize the onco-functional balance of LGG surgery. To this end, an objective neuropsychological assessment has to be achieved in a more systematic manner before and after resection. Early postoperative cognitive rehabilitation is also recommended, whenever needed.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.