ArticleBiological psychiatry. Cognitive neuroscience and neuroimaging2017
Distinct responses to predictable and unpredictable threat in anxiety pathologies: effect of panic attack.
Article in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Moving towards specificity: A systematic review of cue features associated with reward and punishment in anorexia nervosa.Clinical psychology review · 2020Pooled it
- How Temporal Predictability of Threat and Action Preparation Affect Defensive Freezing Responses.Psychophysiology · 2026Article
- Activity of Corticotropin-Releasing Factor Neurons in the Bed Nucleus of the Stria Terminalis Reduces Anxiety-Potentiated Startle in Female Rats in an Estrous Phase-Dependent Manner.Biological psychiatry · 2026Article
- Exploration of wearable sensor measures associated with panic attacks differs across mental health conditions.Frontiers in digital health · 2026Article
- Eye movements reveal age differences in how arousal modulates saliency priority but not attention processing speed.bioRxiv : the preprint server for biology · 2024Article
- Transdiagnostic Fear and Anxiety: Prospective Prediction Using the No-Threat, Predictable Threat, and Unpredictable Threat Task.Biological psychiatry global open science · 2023Article
- Don't worry, it won't be fine. Contributions of worry and anxious arousal to startle responses and event-related potentials in threat anticipation.Cognitive, affective & behavioral neuroscience · 2023Article
- Are Fear and Anxiety Truly Distinct?Biological psychiatry global open science · 2022Review
- Threat-of-shock decreases emotional interference on affective stroop performance in healthy controls and anxiety patients.The European journal of neuroscience · 2022Article
- Ethnic differences in behavioral and physiological indicators of sensitivity to threat.Journal of anxiety disorders · 2022Article
- Dissociable impact of childhood trauma and deployment trauma on affective modulation of startle.Neurobiology of stress · 2021Article
- The prevalence risk of anxiety and its associated factors among university students in Malaysia: a national cross-sectional study.BMC public health · 2021Article
- Fear Potentiated Startle in Children With Autism Spectrum Disorder: Association With Anxiety Symptoms and Amygdala Volume.Autism research : official journal of the International Society for Autism Research · 2021Article
- From Uncertainty to Anxiety: How Uncertainty Fuels Anxiety in a Process Mediated by Intolerance of Uncertainty.Neural plasticity · 2020Review
- Resting-state connectivity of the bed nucleus of the stria terminalis and the central nucleus of the amygdala in clinical anxietyJournal of psychiatry & neuroscience : JPN · 2019Article
- Neural correlates of predictable and unpredictable threat in internalizing psychopathology.Neuroscience letters · 2019Article
- Exercise decreases defensive responses to unpredictable, but not predictable, threat.Depression and anxiety · 2018Article
- If or when? Uncertainty's role in anxious anticipation.Psychophysiology · 2018Article
- The relationship between dlPFC activity during unpredictable threat and COTranslational psychiatry · 2017Article
- Activity alterations in the bed nucleus of the stria terminalis and amygdala during threat anticipation in generalized anxiety disorder.Social cognitive and affective neuroscience · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundDelineating specific clinical phenotypes of anxiety disorders is a crucial step toward better classification and understanding of these conditions. The present study sought to identify differential aversive responses to predictable and unpredictable threat of shock in healthy comparisons and in non-medicated anxiety patients with and without a history of panic attacks (PAs).
method143 adults (72 healthy controls; 71 patients with generalized anxiety disorder (GAD) or/and social anxiety disorder (SAD), 24 with and 47 without PAs) were exposed to three conditions: 1) predictable shocks signaled by a cue, 2) unpredictable shocks, and 3) no shock. Startle magnitude was used to assess aversive responses.
resultsAcross disorders, a PA history was specifically associated with hypersensitivity to unpredictable threat. By disorder, SAD was associated with hypersensitivity to predictable threat, whereas GAD was associated with exaggerated baseline startle.
conclusionsThese results identified three physiological patterns. The first is hypersensitivity to unpredictable threat in individuals with PAs. The second is hypersensitivity to predictable threat, which characterizes SAD. The third is enhanced baseline startle in GAD, which may reflect propensity for self-generated anxious thoughts in the absence of imminent danger. These results inform current thinking by linking specific clinical features to particular physiology profiles.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.