ArticleBiological psychiatry. Cognitive neuroscience and neuroimaging2017
Psychotropic medication use in autism spectrum disorders may affect functional brain connectivity.
Article in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- Neural circuit disruptions of eye gaze processing in autism spectrum disorder and schizophrenia: An activation likelihood estimation meta-analysis.Schizophrenia research · 2024Pooled it
- Functional connectivity patterns differ as a function of co-occurring attentional problems in preschoolers with autism.Journal of neurodevelopmental disorders · 2025Article
- Global motion coherent deficits in individuals with autism spectrum disorder and their family members are associated with retinal function.Scientific reports · 2025Article
- The Impact of Atlas Parcellation on Functional Connectivity Analysis Across Six Psychiatric Disorders.Human brain mapping · 2025Article
- Structural and functional coupling alterations in autism spectrum disorder with and without comorbid attention deficit hyperactivity disorder.Frontiers in psychiatry · 2025Article
- Cooking for disability: a pilot study on nutritional interventions for mental health support in adults with autism spectrum disorder.Frontiers in psychiatry · 2025Article
- Brain functional gradient and structure features in adolescent and adult autism spectrum disorders.Human brain mapping · 2024Article
- The use of psychotropic medications in autistic individuals (21 years and younger) in Western Australia: A preliminary investigation.Autism : the international journal of research and practice · 2024Article
- Functional connectivity in autism spectrum disorder evaluated using rs-fMRI and DKI.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Delineating Transdiagnostic Subtypes in Neurodevelopmental Disorders via Contrastive Graph Machine Learning of Brain Connectivity Patterns.bioRxiv : the preprint server for biology · 2024Article
- Functional brain network alterations in the co-occurrence of autism spectrum disorder and attention deficit hyperactivity disorder.European child & adolescent psychiatry · 2024Article
- Autism in Africa: prevalence, diagnosis, treatment and the impact of social and cultural factors on families and caregivers: a review.Annals of medicine and surgery (2012) · 2023Review
- Increased functional activity, bottom-up and intrinsic effective connectivity in autism.NeuroImage. Clinical · 2023Article
- Modern views of machine learning for precision psychiatry.Patterns (New York, N.Y.) · 2022Review
- Amygdala-prefrontal connectivity in children with maladaptive aggression is modulated by social impairment.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Altered Cerebellum Spontaneous Activity in Juvenile Autism Spectrum Disorders Associated with Clinical Traits.Journal of autism and developmental disorders · 2022Article
- Blood Oxygen Level-Dependent Lag Patterns Differ Between Rest and Task Conditions, but Are Largely Typical in Autism.Brain connectivity · 2022Article
- Are medical students in Palestine adequately trained to care for individuals with autism spectrum disorders? A multicenter cross-sectional study of their familiarity, knowledge, confidence, and willingness to learn.BMC medical education · 2021Article
- Altered Thalamocortical Connectivity in 6-Week-Old Infants at High Familial Risk for Autism Spectrum Disorder.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Structural, Functional, and Molecular Imaging of Autism Spectrum Disorder.Neuroscience bulletin · 2021Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundPrescription of psychotropic medications is common in autism spectrum disorders (ASDs), either off-label or to treat comorbid conditions such as ADHD or depression. Psychotropic medications are intended to alter brain function. Yet, studies investigating the functional brain organization in ASDs rarely take medication usage into account. This could explain some of the inconsistent findings of atypical brain network connectivity reported in the autism literature.
methodsThe current study tested whether functional connectivity patterns, as assessed with functional magnetic resonance imaging (fMRI), differed in a cohort of 49 children and adolescents with ASDs based on psychotropic medication status, and in comparison with 50 matched typically developing (TD) participants. Twenty-five participants in the ASD group (51%) reported current psychotropic medication usage, including stimulants, antidepressants, antipsychotics, and anxiolytics. Age, IQ, head motion, and ASD symptom severity did not differ between groups. Whole-brain functional connectivity between 132 regions of interest was assessed.
resultsDifferent functional connectivity patterns were identified in the ASD group taking psychotropic medications (ASD-on), as compared to the TD group and the ASD subgroup not using psychotropic medications (ASD-none). The ASD-on group showed distinct underconnectivity between the cerebellum and basal ganglia but cortico-cortical overconnectivity compared to the TD group. Cortical underconnectivity relative to the TD pattern, on the other hand, was pronounced in the ASD-none group.
conclusionsThese results suggest that psychotropic medications may affect functional connectivity, and that medication status should be taken into consideration when studying brain function in autism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.