ArticleOpen medicine (Warsaw, Poland)2017
The Fountain of Youth: A Tale of Parabiosis, Stem Cells, and Rejuvenation.
Article in Open medicine (Warsaw, Poland), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
35 citing papers in PubMed, 64 citations in OpenAlex.
- From complexity to clarity: aging bone marrow niche in bone and blood regeneration and malignancy.Bone research · 2026Review
- Immortality Reconsidered: Clinical Challenges at the Frontier of Plastic Surgery.Journal of clinical medicine · 2025Review
- Aging and immunity: the age-old tango.Genes & development · 2025Review
- Systemic Rejuvenating Interventions: Perspectives on Neuroinflammation and Blood-Brain Barrier Integrity.Neurochemical research · 2025Review
- Comparing the effect of plasma therapy with estradiol valerate in motor and cognitive behavioral disorders in ovariectomized old rats: Behavioral, biochemical, and protein expression.Iranian journal of basic medical sciences · 2025Article
- Blood-based therapies to combat neurodegenerative diseases.Metabolic brain disease · 2024Review
- Antiaging Strategies and Remedies: A Landscape of Research Progress and Promise.ACS chemical neuroscience · 2024Review
- Reversal of biological age in multiple rat organs by young porcine plasma fraction.GeroScience · 2024Article
- Multi-omic rejuvenation and life span extension on exposure to youthful circulation.Nature aging · 2023Article
- Rejuvenating effects of young extracellular vesicles in aged rats and in cellular models of human senescence.Scientific reports · 2023Article
- Remyelination and Ageing: Ethical Considerations of Using Surgically Joined Animals in Research.Journal of undergraduate neuroscience education : JUNE : a publication of FUN, Faculty for Undergraduate Neuroscience · 2023Article
- Stroke-Induced Neurological Dysfunction in Aged Mice Is Attenuated by Preconditioning with Young Sca-1+ Stem Cells.Stem cells (Dayton, Ohio) · 2022Article
- A cardioimmunologist's toolkit: genetic tools to dissect immune cells in cardiac disease.Nature reviews. Cardiology · 2022Review
- In vivo transcriptomic profiling using cell encapsulation identifies effector pathways of systemic aging.eLife · 2022Article
- Recent Neurotherapeutic Strategies to Promote Healthy Brain Aging: Are we there yet?Aging and disease · 2022Review
- Chronic Antidiabetic Actions of Leptin: Evidence From Parabiosis Studies for a CNS-Derived Circulating Antidiabetic Factor.Diabetes · 2021Article
- dCubilin- or dAMN-mediated protein reabsorption in Drosophila nephrocytes modulates longevity.Disease models & mechanisms · 2021Article
- Higher senescence associated secretory phenotype and lower defense mediator in urinary extracellular vesicles of elders with and without Parkinson disease.Scientific reports · 2021Article
- Aged hematopoietic stem cells are refractory to bloodborne systemic rejuvenation interventions.The Journal of experimental medicine · 2021Article
- Cardio- and Neurometabolic Adipobiology: Consequences and Implications for Therapy.International journal of molecular sciences · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transfusion (or drinking) of blood or of its components has been thought as a rejuvenation method since ancient times. Parabiosis, the procedure of joining two animals so that they share each others blood circulation, has revitalized the concept of blood as a putative drug. Since 2005, a number of papers have reported the anti-ageing effect of heterochronic parabiosis, which is joining an aged mouse to a young partner. The hallmark of aging is the decline of regenerative properties in most tissues, partially attributed to impaired function of stem and progenitor cells. In the parabiosis experiments, it was elegantly shown that factors derived from the young systemic environment are able to activate molecular signaling pathways in hepatic, muscle or neural stem cells of the old parabiont leading to increased tissue regeneration. Eventually, further studies have brought to identify some soluble factors in part responsible for these rejuvenating effects, including the chemokine CCL11, the growth differentiation factor 11, a member of the TGF-β superfamily, and oxytocin. The question about giving whole blood or specific factors in helping rejuvenation is open, as well as the mechanisms of action of these factors, deserving further studies to be translated into the life of (old) human beings.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.