Evidence map›Paper›PMID 29104936›Full record

ArticlemSphere

Tuberculosis State Is Associated with Expression of Toll-Like Receptor 2 in Sputum Macrophages.

Karim Lakehal, David Levine, Kathleen F Kerr, Pooja Vir, Natalie Bruiners, Alfred Lardizabal, Maria Laura Gennaro, Richard Pine

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mSphere. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Karim LakehalPublic Health Research Institute, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, New Jersey, USA.
David LevineDepartment of Biostatistics, University of Washington, Seattle, Washington, USA.
Kathleen F KerrDepartment of Biostatistics, University of Washington, Seattle, Washington, USA.
Pooja VirPublic Health Research Institute, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, New Jersey, USA.
Natalie BruinersPublic Health Research Institute, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, New Jersey, USA.
Alfred LardizabalGlobal Tuberculosis Institute, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, New Jersey, USA.
Maria Laura GennaroPublic Health Research Institute, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, New Jersey, USA.
Richard PinePublic Health Research Institute, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, New Jersey, USA.
Rutgers, The State University of New Jersey · USUniversity of Washington · US

Funding

Mapping and modeling host-pathogen interactions in TB latency and reactivationR01HL106788 · NHLBI · UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL · PI BALAZSI, GABOR, GENNARO, MARIA LAURA · 2010 to 2013
$3.1M
Data Coordinating Center for Systems Biology Approach to the Mechanisms of TBR01HL106800 · NHLBI · UNIVERSITY OF WASHINGTON · PI BENNETT, SIIRI, KERR, KATHLEEN F. · 2010 to 2013
$2.3M
NHLBI NIH HHS R01 HL106788NHLBI NIH HHS R01 HL106800
6 · The paper itself

Abstract

During tuberculosis, macrophages are critical for both pathogen survival and host immune activation. Since expression of particular cell surface markers reflects cell function, we used flow cytometry to measure the abundance of surface markers associated with polarity, lipid uptake, or pattern recognition on macrophages found in induced sputum. Nine macrophage surface markers were examined from three groups of donors: infection-free, latent tuberculosis infection, and active pulmonary tuberculosis. Using a trend test, we found that expression of Toll-like receptor 2 was greater from absence of infection to latent infection and from latent infection to active tuberculosis. The results point to the possibility that innate immune cell phenotypes be used to distinguish among tuberculosis infection stages. Moreover, this study shows that readily accessible sputum macrophages have potential for tuberculosis diagnosis and prognosis.

Indexed as

immunophenotypinginnate immunitymacrophage surface markerspattern recognition receptorstuberculosis biomarkers

Identifiers

PMID29104936
PMCPMC5663984
OpenAlexW2767139155

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.