Evidence map›Paper›PMID 29104935›Full record

ArticlemSphere

Modeling Group B

Brandon J Kim, Olivia B Bee, Maura A McDonagh, Matthew J Stebbins, Sean P Palecek, Kelly S Doran, Eric V Shusta

Open access · goldAbstract read
In one paragraph

Article in mSphere. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 58 citations in OpenAlex.

  1. Article
  2. CRISPR interference in aJournal of bacteriology · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Microbiology resource announcements · 2024
    Article
  10. Article
  11. Article
  12. Group BJournal of bacteriology · 2024
    Article
  13. Review
  14. Current neuropharmacology · 2024
    Review
  15. Article
  16. Article
  17. Review
  18. Group BPathogens (Basel, Switzerland) · 2022
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Brandon J KimDepartment of Chemical and Biological Engineering, University of Wisconsin, Madison, Wisconsin, USA.
Olivia B BeeDepartment of Chemical and Biological Engineering, University of Wisconsin, Madison, Wisconsin, USA.
Maura A McDonaghDepartment of Chemical and Biological Engineering, University of Wisconsin, Madison, Wisconsin, USA.
Matthew J StebbinsDepartment of Chemical and Biological Engineering, University of Wisconsin, Madison, Wisconsin, USA.
Sean P PalecekDepartment of Chemical and Biological Engineering, University of Wisconsin, Madison, Wisconsin, USA.
Kelly S DoranDepartment of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, USA.
Eric V ShustaDepartment of Chemical and Biological Engineering, University of Wisconsin, Madison, Wisconsin, USA.
University of Wisconsin–Madison · USUniversity of Colorado Denver · US

Funding

BIOTECHNOLOGY TRAINING PROGRAMT32GM008349 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI FOX, BRIAN G · 1989 to 2019
$22.5M
Blood-brain barrier in bacterial meningitisR01NS051247 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DORAN, KELLY S · 2006 to 2015
$3.2M
RXRalpha and PPARdelta Signaling as Novel Regulators of the Blood-Brain BarrierR01NS083688 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI SHUSTA, ERIC V · 2013 to 2017
$1.9M
NIGMS NIH HHS T32 GM008349NINDS NIH HHS R01 NS051247NINDS NIH HHS R01 NS083688
6 · The paper itself

Abstract

Bacterial meningitis is a serious infection of the central nervous system (CNS) that occurs after bacteria interact with and penetrate the blood-brain barrier (BBB). The BBB is comprised of highly specialized brain microvascular endothelial cells (BMECs) that function to separate the circulation from the CNS and act as a formidable barrier for toxins and pathogens. Certain bacteria, such as

Indexed as

blood-brain barriergroup B Streptococcusstem cells

Identifiers

PMID29104935
PMCPMC5663983
OpenAlexW2765950493

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.