ArticleACS biomaterials science & engineering2017
Prevention of Oxygen Inhibition of PolyHIPE Radical Polymerization using a Thiol-based Crosslinker.
Article in ACS biomaterials science & engineering, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed.
- Progress in process parameters and mechanism research of polymer emulsion preparation.RSC advances · 2024Review
- Hydroxyapatite nanoparticle-modified porous bone grafts with improved cell attachment.Journal of materials chemistry. B · 2023Article
- Designing Superlubricious Hydrogels from Spontaneous Peroxidation Gradients.ACS applied materials & interfaces · 2023Article
- Article
- PoreScript: Semi-automated pore size algorithm for scaffold characterization.Bioactive materials · 2022Article
- Thiol-Ene Cross-linking of Poly(ethylene glycol) within High Internal Phase Emulsions: Degradable Hydrophilic PolyHIPEs for Controlled Drug Release.Macromolecules · 2021Article
- Article
- Porous Polymers from High Internal Phase Emulsions as Scaffolds for Biological Applications.Polymers · 2021Review
- Article
- Basic Principles of Emulsion Templating and Its Use as an Emerging Manufacturing Method of Tissue Engineering Scaffolds.Frontiers in bioengineering and biotechnology · 2020Review
- Porous PolyHIPE microspheres for protein delivery from an injectable bone graft.Acta biomaterialia · 2019Article
- Modeling the Optimal Conditions for Improved Efficacy and Crosslink Depth of Photo-Initiated Polymerization.Polymers · 2019Article
- Article
- LncRNAs and miRs as epigenetic signatures in diabetic cardiac fibrosis: new advances and perspectives.Endocrine · 2018Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Polymerized high internal phase emulsions (polyHIPEs) are highly porous constructs currently under investigation as tissue engineered scaffolds. We previously reported on the potential of redox-initiated polyHIPEs as injectable bone grafts that space fill irregular defects with improved integration and rapid cure. Upon subsequent investigation, the radical-initiated cure of these systems rendered them susceptible to oxygen inhibition with an associated increase in uncured macromer in the clinical setting. In the current study, polyHIPEs with increased resistance to oxygen inhibition were fabricated utilizing a tetrafunctional thiol, pentaerythritol tetrakis(3-mercaptoproprionate), and the biodegradable macromer, propylene fumarate dimethacrylate. Increased concentrations of the tetrathiol additive provided improved oxygen resistance as confirmed by polyHIPE gel fraction while retaining the requisite rapid cure rate, compressive properties, and pore architecture for use as an injectable bone graft. Additionally, thiol-methacrylate polyHIPEs exhibited increased degradation under accelerated conditions and supported critical markers of human mesenchymal stem cell activity. In summary, we have improved upon current methods of fabricating injectable polyHIPE grafts to meet translational design goals of improved polymerization kinetics under clinically relevant conditions without sacrificing key scaffold properties.
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Registered trials
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