Evidence map›Paper›PMID 29104818›Full record

ArticleACS macro letters2017

Design and Synthesis of New Sulfur-Containing Hyperbranched Polymer and Theranostic Nanomaterials for Bimodal Imaging and Treatment of Cancer.

Blaze Heckert, Tuhina Banerjee, Shoukath Sulthana, Shuguftha Naz, Riyadh Alnasser, Deaven Thompson, Guillaume Normand, Jan Grimm, J Manuel Perez, Santimukul Santra

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS macro letters, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Blaze HeckertDepartment of Chemistry, Pittsburg State University, 1701 S. Broadway Street, Pittsburg, KS 66762, USA.
Tuhina BanerjeeDepartment of Chemistry, Pittsburg State University, 1701 S. Broadway Street, Pittsburg, KS 66762, USA.
Shoukath SulthanaDepartment of Chemistry, Pittsburg State University, 1701 S. Broadway Street, Pittsburg, KS 66762, USA.
Shuguftha NazDepartment of Chemistry, Pittsburg State University, 1701 S. Broadway Street, Pittsburg, KS 66762, USA.
Riyadh AlnasserDepartment of Chemistry, Pittsburg State University, 1701 S. Broadway Street, Pittsburg, KS 66762, USA.
Deaven ThompsonDepartment of Chemistry, Pittsburg State University, 1701 S. Broadway Street, Pittsburg, KS 66762, USA.
Guillaume NormandDepartment of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.
Jan GrimmDepartment of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.
J Manuel PerezNanoscience Technology Center, University of Central Florida, Orlando, FL 32826, USA.
Santimukul SantraDepartment of Chemistry, Pittsburg State University, 1701 S. Broadway Street, Pittsburg, KS 66762, USA.
Pittsburg State University · USMemorial Sloan Kettering Cancer Center · USUniversity of Central Florida · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Mentoring CoreP20GM103418 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI SUSAN J. BROWN · 2012 to 2026
$63.0M
Smart and self-reporting clinical nano carriers for drug deliveryR01CA215700 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI GRIMM, JAN · 2017 to 2021
$3.5M
Cerenkov-emission based nanosensors to detect biologic activities in vivoR01EB014944 · NIBIB · SLOAN-KETTERING INST CAN RESEARCH · PI GRIMM, JAN · 2012 to 2015
$1.6M
Polymeric nanoparticles with imaging capability for therapeutic peptide deliveryR01EB019288 · NIBIB · UNIVERSITY OF CENTRAL FLORIDA · PI KHALED, ANNETTE R, PEREZ, J MANUEL · 2014 to 2017
$1.2M
NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA215700NIBIB NIH HHS R01 EB014944NIBIB NIH HHS R01 EB019288NIGMS NIH HHS P20 GM103418
6 · The paper itself

Abstract

In this study, we have synthesized a new hyperbranched polyester polymer containing sulfur-pendants (HBPE-S) in the branching points. This HBPE-S polymer is composed of spherical shaped, aliphatic three-dimensional architecture with carboxylic acid groups on the surface. The presence of sulfur pendants in the polymeric cavities demonstrated important role in the effective encapsulation of Bi-DOTA complexes ([Bi] = 5.21 μM), when compared to the previously reported polymer without sulfur pendants (HBPE, [Bi] = 1.07 x 10-3 μM). Higher X-ray blocking capability and excellent X-ray contrast images were obtained from Bi-DOTA encapsulating HBPE-S polymeric nanoparticles when compared with that of HBPE nanoparticles. In addition, the HBPE-S polymer's spherical structure with amphiphilic cavities allow for the successful encapsulation of anti-tumor drugs and optical dyes, indicating suitable for delivery of wide-range of theranostic agents for cancer diagnosis and treatment. Therapeutic drug taxol encapsulating, folic acid decorated HBPE-S-Fol nanoparticles showed more than 80% of lung carcinoma cell death within 24 h of incubation. Cell viability and microscopic experiments also confirmed for the targeted delivery, thereby minimizing toxicity to healthy tissues. Taken together, new HBPE-S polymer and multimodal theranostic nanoplatforms were synthesized with enhanced X-ray blocking capability for the effective cancer targeting and treatment monitoring.

Identifiers

PMID29104818
PMCPMC5667566
OpenAlexW2589956477

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.