Evidence map›Paper›PMID 29104671›Full record

ArticleJournal of innovative optical health sciences2017

Effect of pneumatic compression therapy on lymph movement in lymphedema-affected extremities, as assessed by near-infrared fluorescence lymphatic imaging.

Melissa B Aldrich, Deborah Gross, John Rodney Morrow, Caroline E Fife, John C Rasmussen

Open access · goldAbstract read
In one paragraph

Article in Journal of innovative optical health sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. The Utility of Lymphatic Massage in Cosmetic Procedures.Aesthetic surgery journal. Open forum · 2023
    Review
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Melissa B AldrichCenter for Molecular Imaging, The Brown Institute for Molecular Medicine, UTHealth, Houston, Texas.
Deborah GrossMego Afek/Lympha Press USA, Freehold, New Jersey.
John Rodney MorrowCenter for Molecular Imaging, The Brown Institute for Molecular Medicine, UTHealth, Houston, Texas.
Caroline E FifeCHI St. Luke's Health, The Woodlands Hospital, The Woodlands, Texas.
John C RasmussenCenter for Molecular Imaging, The Brown Institute for Molecular Medicine, UTHealth, Houston, Texas.
Brown Foundation · USInstitute for Molecular Medicine · USOpexa Therapeutics (United States) · USThe University of Texas Health Science Center at Houston · US

Funding

Task Specific Project 4U54CA136404 · NCI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI SEVICK, EVA M. · 2008 to 2012
$5.1M
Lymphatic and systemic immunity changes in post-radiation lymphedema developmentR01CA201487 · NCI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ALDRICH, MELISSA B · 2016 to 2020
$1.8M
NCI NIH HHS R01 CA201487NCI NIH HHS U54 CA136404
6 · The paper itself

Abstract

Previous studies have shown cost effectiveness and quality-of-life benefit of pneumatic compression therapy (PCT) for lymphedema. Insurers, such as the Centers for Medicare/Medicaid (CMS), however, desire visual proof that PCT moves lymph. Near-infrared fluorescence lymphatic imaging (NIRFLI) was used to visualize lymphatic anatomy and function in four subjects with primary and cancer treatment-related lymphedema (LE) of the lower extremities before, during, and after pneumatic compression therapy (PCT). Optically transparent and windowed PCT garments allowed visualization of lymph movement during single, one-hour PCT treatment sessions. Visualization revealed significant extravascular and lymphatic vascular movement of intradermally injected dye in all subjects. In one subject with sufficient patent lymphatic vessels to allow quantification of lymph pumping velocities and frequencies, these values were significantly increased during and after PCT as compared to pre-treatment values. Lymphatic contractile activity in patent lymphatic vessels occurred in concert with the sequential cycling of PCT. Direct visualization revealed increased lymphatic function, during and after PCT therapy, in all lymphedema-affected extremities. Further studies are warranted to assess the effects of PCT pressure and sequences on lymph uptake and movement.

Identifiers

PMID29104671
PMCPMC5665410
OpenAlexW2518253572

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.