ArticleFrontiers in neuroscience2017
The Effect of Lamotrigine and Levetiracetam on TMS-Evoked EEG Responses Depends on Stimulation Intensity.
Article in Frontiers in neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 5 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 5 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- Pooled it
- Lamotrigine add-on therapy for drug-resistant focal epilepsy.The Cochrane database of systematic reviews · 2023Pooled it
- Transcranial magnetic stimulation-evoked electroencephalography responses as biomarkers for epilepsy: A review of study design and outcomes.Human brain mapping · 2023Pooled it
- Lamotrigine add-on therapy for drug-resistant focal epilepsy.The Cochrane database of systematic reviews · 2020Pooled it
- A systematic review of TMS and neurophysiological biometrics in patients with schizophrenia.Journal of psychiatry & neuroscience : JPNPooled it
- Transcranial magnetic stimulation as a translational biomarker for AMPA receptor modulation.Translational psychiatry · 2021Trial
- The effects of NMDA receptor blockade on TMS-evoked EEG potentials from prefrontal and parietal cortex.Scientific reports · 2020Trial
- Tensor decomposition of TMS-induced EEG oscillations reveals data-driven profiles of antiepileptic drug effects.Scientific reports · 2019Trial
- Effects of antiepileptic drugs on cortical excitability in humans: A TMS-EMG and TMS-EEG study.Human brain mapping · 2019Trial
- Associations between pre-to-post TMS-evoked potential changes and motor sequence learning across retention intervals.Frontiers in human neuroscience · 2026Article
- Resting motor threshold in navigated transcranial magnetic stimulation: relationship between inter-individual variance and distinct clinical and anatomical factors.Acta neurochirurgica · 2025Article
- Stability of transcranial magnetic stimulation electroencephalogram evoked potentials in pediatric epilepsy.Scientific reports · 2024Article
- Neural Circuitry-Related Biomarkers for Drug Development in Psychiatry: An Industry Perspective.Advances in neurobiology · 2024Review
- Reduced approach disposition in familial risk for depression: Evidence from time-frequency alpha asymmetries.PloS one · 2024Article
- Identifying subcortical connectivity during brain tumor surgery: a multimodal study.Brain structure & function · 2023Article
- Lamotrigine Attenuates Neuronal Excitability, Depresses GABA Synaptic Inhibition, and Modulates Theta Rhythms in Rat Hippocampus.International journal of molecular sciences · 2021Article
- Dynamic tractography: Integrating cortico-cortical evoked potentials and diffusion imaging.NeuroImage · 2020Article
- Neurophysiological markers of disease severity and cognitive dysfunction in major depressive disorder: A TMS-EEG study.International journal of clinical and health psychology : IJCHPArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
The combination of transcranial magnetic stimulation and electroencephalography (TMS-EEG) has uncovered underlying mechanisms of two anti-epileptic medications: levetiracetam and lamotrigine. Despite their different mechanism of action, both drugs modulated TMS-evoked EEG potentials (TEPs) in a similar way. Since both medications increase resting motor threshold (RMT), the current aim was to examine the similarities and differences in post-drug TEPs, depending on whether stimulation intensity was adjusted to take account of post-drug RMT increase. The experiment followed a placebo controlled, double blind, crossover design, involving a single dose of either lamotrigine or levetiracetam. When a drug-induced increase of RMT occurred, post-drug measurements involved two blocks of stimulations, using unadjusted and adjusted stimulation intensity. A cluster based permutation analysis of differences in TEP amplitude between adjusted and unadjusted stimulation intensity showed that lamotrigine induced a stronger modulation of the N45 TEP component compared to levetiracetam. Results highlight the impact of adjusting stimulation intensity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.