ArticleAdvanced synthesis & catalysis2017
A Biocatalytic Route to Highly Enantioenriched β-Hydroxydioxinones.
Article in Advanced synthesis & catalysis, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed.
- An account on using bio-renewable solvents in organic synthesis: advances, prospects, and challenges.RSC advances · 2026Review
- Application of Biobased Solvents in Asymmetric Catalysis.Molecules (Basel, Switzerland) · 2022Review
- Replacement of Less-Preferred Dipolar Aprotic and Ethereal Solvents in Synthetic Organic Chemistry with More Sustainable Alternatives.Chemical reviews · 2022Review
- Synthetic Derivatives of Ciclopirox are Effective Inhibitors ofACS omega · 2021Article
- Biocatalyzed Redox Processes Employing Green Reaction Media.Molecules (Basel, Switzerland) · 2020Review
- Targeted Covalent Inhibition of Telomerase.ACS chemical biology · 2020Article
- Cyclopentyl Methyl Ether: An Elective Ecofriendly Ethereal Solvent in Classical and Modern Organic Chemistry.ChemSusChem · 2019Review
- An Enantioselective Cross-Dehydrogenative Coupling Catalysis Approach to Substituted Tetrahydropyrans.Journal of the American Chemical Society · 2018Article
- Lewis-Acid-Mediated Benzotriazole Ring Cleavage (BtRC) Strategy for the Synthesis of 2-Aryl Benzoxazoles fromACS omega · 2017Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
A novel biocatalytic system to access a wide variety of β-hydroxydioxinones from β-ketodioxinones employing commercial engineered ketoreductases has been developed. This practical system provides a remarkably straightforward solution to limitations in accessing certain chemical scaffolds common in β-hydroxydioxinones that are of great interest due to their diversification capabilities. A few highlights of this system are that it is high yielding, highly enantioselective, and chromatography-free. We have demonstrated both a wide substrate scope and a high degree of scalability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.