ArticleInternational journal of biological sciences2017
Identification and Analysis of P53-Mediated Competing Endogenous RNA Network in Human Hepatocellular Carcinoma.
Article in International journal of biological sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 60 citations in OpenAlex.
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- miR-6881-3p contributes to diminished ovarian reserve by regulating granulosa cell apoptosis by targeting SMAD4.Reproductive biology and endocrinology : RB&E · 2024Article
- From sequencing to validation: NGS-based exploration of plasma miRNA in papillary thyroid carcinoma.Frontiers in oncology · 2024Article
- Landscape of MicroRNA Regulatory Network Architecture and Functional Rerouting in Cancer.Cancer research · 2023Article
- Changes in patient peripheral blood cell microRNAs after total body irradiation during hematopoietic stem cell transplantation.Annals of translational medicine · 2022Article
- Multivariate competing endogenous RNA network characterization for cancer microRNA biomarker discovery: a novel bioinformatics model with application to prostate cancer metastasis.Precision clinical medicine · 2022Article
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- Competitive learning suggests circulating miRNA profiles for cancers decades prior to diagnosis.RNA biology · 2020Article
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- Profiling and functional analysis of differentially expressed circular RNAs in high glucose-induced human umbilical vein endothelial cells.FEBS open bio · 2019Article
- CircPOMT1 and circMCM3AP inhibit osteogenic differentiation of human adipose-derived stem cells by targeting miR-6881-3p.American journal of translational research · 2019Article
- Construction of implantation failure related lncRNA-mRNA network and identification of lncRNA biomarkers for predicting endometrial receptivity.International journal of biological sciences · 2018Article
- Analysis of Transcription Factor-Related Regulatory Networks Based on Bioinformatics Analysis and Validation in Hepatocellular Carcinoma.BioMed research international · 2018Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent studies have indicated that long non-coding RNAs (lncRNAs) and mRNA function as competing endogenous RNAs (ceRNAs) that compete to bind to shared microRNA (miRNA) recognition elements (MREs) to perform specific biological functions during tumorigenesis. The tumor suppressor p53 is a master regulator of cancer-related biological processes by acting as a transcription factor to regulate target genes including miRNA and lncRNA. However, the mechanism in human hepatocellular carcinoma and whether p53-mediated RNA targets could form ceRNA network remain unclear. Here, we identified a series of differential expressed miRNAs, lncRNA and mRNA which were potentially regulated by p53 using RNA sequencing in HepG2. Genomic characteristics comparative analysis showed significant differences between mRNAs and lncRNAs. By integrating experimentally confirmed Ago2 and p53 binding sites, we constructed a highly reliable p53-mediated ceRNA network using hypergeometric test. The KEGG pathway enrichment analysis showed that the ceRNA network highly enriched in the cancer or p53-associated signaling pathways. Finally, using betweenness centrality analysis, we identified five master miRNAs (hsa-miR-3620-5p, hsa-miR-3613-3p, hsa-miR-6881-3p, hsa-miR-6087 and hsa-miR-18a-3p) that regulated most of the target RNAs, suggesting these miRNAs play central roles in the whole p53-mediated ceRNAs network. Taken together, our results provide a new regulatory mechanism of p53 networks for future studies in cancer therapeutics.
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