Evidence map›Paper›PMID 29104486›Full record

ArticleInternational journal of medical sciences2017

Tanshinone IIA Inhibits β-Catenin Nuclear Translocation and IGF-2R Activation via Estrogen Receptors to Suppress Angiotensin II-Induced H9c2 Cardiomyoblast Cell Apoptosis.

Ya-Fang Chen, Cecilia Hsuan Day, Nien-Hung Lee, Yu-Feng Chen, Jaw-Ji Yang, Chih-Hsueh Lin, Ray-Jade Chen, Peramaiyan Rajendran, Vijaya Padma Viswanadha, Chih-Yang Huang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of medical sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.9field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 27 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
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  5. Review
  6. Frontiers in pharmacology · 2025
    Review
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  10. Frontiers in pharmacology · 2022
    Review
  11. Article
  12. Review
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  15. Frontiers in pharmacology · 2019
    Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 8 institutions in 2 countries.

Ya-Fang ChenGraduate Institute of Basic Medical Science, China Medical University, Taichung 40402, Taiwan.
Cecilia Hsuan DayDepartment of Nursing, MeiHo University, Pingtung 91202, Taiwan.
Nien-Hung LeeGraduate Institute of Basic Medical Science, China Medical University, Taichung 40402, Taiwan.
Yu-Feng ChenSection of Cardiology, Yuan Rung Hospital, Yuanlin, Taiwan.
Jaw-Ji Yang5Institute of Oral Sciences, College of Oral Medicine, Chung Shan Medical University, Taichung40201, Taiwan.
Chih-Hsueh LinDepartment of Family Medicine, China Medical University Hospital, Taichung, Taiwan.
Ray-Jade ChenDepartment of Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei11031, Taiwan.
Peramaiyan RajendranGraduate Institute of Basic Medical Science, China Medical University, Taichung 40402, Taiwan.
Vijaya Padma ViswanadhaDepartment of Biotechnology, Bharathiar University, Coimbatore-641 046, India.
Chih-Yang HuangGraduate Institute of Basic Medical Science, China Medical University, Taichung 40402, Taiwan.
China Medical University · TWAsia University · TWBharathiar University · INChina Medical University Hospital · TWChung Shan Medical University · TWMeiho University · TWTaichung Veterans General Hospital · TWTaipei Medical University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardiomyopathy involves changes in the myocardial ultra-structure, hypertrophy, apoptosis, fibrosis and inflammation. Angiotensin II (AngII) stimulates the expression of insulin like-growth factors (IGF-2) and IGF-2 receptor (IGF-2R) in H9c2 cardiomyoblasts and subsequently leads to apoptosis. Estrogen receptors protect cardiomyocytes from apoptosis and fibrosis. Tanshinone IIA (TSN), a main active ingredient from Danshen, has been shown to protect cardiomyocytes from death caused by different stress signals. Estrogen receptor α (ER) is required for the rapid activation of the IGF-1R signaling cascade. This study aimed to investigate whether TSN protected H9c2 cardiomyocytes from AngII-induced activation of IGF-2R pathway and hypertrophy via ERs. We found that AngII caused the reduction in IGF-1R phosphorylation and the elevation of β-catenin and IGF-2R levels. This was reversed by increasing doses of TSN and of caspase-3 and ERK1/2 phosphorylation mediated by ERs. The phytoestrogen significantly attenuated AngII-induced apoptosis and suppressed the subsequent cardiac remodeling effect. Therefore, TSN reduced the AngII-induced activation of β-catenin and IGF-2R pathways, apoptosis and cardiac remodeling via ERs in H9c2 cardiomyoblasts.

Indexed as

AbietanesAngiotensin IIAnimalsApoptosisbeta CateninCardiomyopathy, HypertrophicCell LineCell NucleusDrugs, Chinese HerbalHumansMyocytes, CardiacPhosphorylationProtein TransportRatsReceptor, IGF Type 2Receptors, EstrogenAbietanesAngiotensin IIbeta CateninCtnnb1 protein, ratdan-shen root extractDrugs, Chinese HerbalReceptor, IGF Type 2Receptors, EstrogentanshinoneAngiotensin IIEstrogen receptorsH9c2 CardiomyoblastsInsulin-like Growth Factor-2 ReceptorTanshinone IIA.β-Catenin

Identifiers

PMID29104486
PMCPMC5666563
OpenAlexW2765699639

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.