Evidence map›Paper›PMID 29104484›Full record

ArticleInternational journal of medical sciences2017

Chlorpheniramine attenuates histamine-mediated aquaporin 5 downregulation in human nasal epithelial cells via suppression of NF-κB activation.

Yung-Lung Chang, Chun-Shu Lin, Hsing-Won Wang, Kai Ren Jian, Shao-Cheng Liu

Open access · goldAbstract read
In one paragraph

Article in International journal of medical sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Aquaporins in Allergic Response: A New Player.Clinical reviews in allergy & immunology · 2025
    Review
  5. Review
  6. Aquaporin-5 Dynamic Regulation.International journal of molecular sciences · 2023
    Review
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 2 countries.

Yung-Lung ChangDepartment of Biochemistry, National Defense Medical Center.
Chun-Shu LinDepartment of Radiation Oncology, Tri-Service General Hospital, National Defense Medical Center.
Hsing-Won WangDepartment of Otolaryngology-Head and Neck Surgery, Tri-Service General Hospital, National Defense Medical Center.
Kai Ren JianDepartment of Biochemistry, National Defense Medical Center.
Shao-Cheng LiuDepartment of Otolaryngology-Head and Neck Surgery, Tri-Service General Hospital, National Defense Medical Center.
National Defense Medical Center · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Aquaporin 5Cells, CulturedChlorpheniramineCyclic AMP Response Element-Binding ProteinDose-Response Relationship, DrugDown-RegulationEpithelial CellsFemaleGene Expression RegulationHistamineHistamine H1 AntagonistsHumansMaleNasal MucosaNF-kappa BPhosphorylationAQP5 protein, humanAquaporin 5ChlorpheniramineCREB1 protein, humanCyclic AMP Response Element-Binding ProteinHistamineHistamine H1 AntagonistsNF-kappa BantihistamineAQP5cAMPCREBhistaminenasal mucosaNF-κB

Identifiers

PMID29104484
PMCPMC5666561
OpenAlexW2767111875

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.