Evidence map›Paper›PMID 29104223›Full record

ArticleMolecules (Basel, Switzerland)2017

Detection of Rare Somatic GNAS Mutation in McCune-Albright Syndrome Using a Novel Peptide Nucleic Acid Probe in a Single Tube.

Fu-Sung Lo, Tai-Long Chen, Chiuan-Chian Chiou

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. McCune-Albright Syndrome: A Case Report and Review of Literature.International journal of molecular sciences · 2023
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Fu-Sung LoDivision of Pediatric Endocrinology & Genetics, Chang Gung Memorial Hospital, Linkou, Taoyuan 333, Taiwan. lofusu@cgmh.org.tw.
Tai-Long ChenMolecular Medicine Research Center, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan. tl.chen@outlook.com.
Chiuan-Chian ChiouMolecular Medicine Research Center, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan. ccchiou@mail.cgu.edu.tw.
Chang Gung University · TW

Funding

NTP INFORMATION SYSTEMS SUPPORT27305C0011 · NIEHS · Z-TECH CORPORATION · 2007 to 2009
$4.3M
PROVIDE RABBITS, RATS, MICE, HAMSTERS, GERBILS, GUINEA PIGS27307C0011 · NIEHS · PI BOLEN, WAYNE · 2007 to 2007
$500k
NIEHS NIH HHS 27305C0011NIEHS NIH HHS 27307C0011NIEHS NIH HHS 27398C0011
6 · The paper itself

Abstract

McCune-Albright syndrome (MAS) is characterized by the triad of precocious puberty, café au lait pigmentation, and polyostotic fibrous dysplasia (FD) of bone, and is caused by post-zygotic somatic mutations-R201H or R201C-in the guanine nucleotide binding protein, alpha stimulating (GNAS) gene. In the present study, a novel peptide nucleic acid (PNA) probe with fluorescent labeling was designed to detect trace amounts of somatic mutant

Indexed as

ChromograninsDNA Mutational AnalysisFibrous Dysplasia, PolyostoticGTP-Binding Protein alpha Subunits, GsHumansMutationPeptide Nucleic AcidsChromograninsGNAS protein, humanGTP-Binding Protein alpha Subunits, GsPeptide Nucleic AcidsGNAS mutationMcCune-Albright syndromepeptide nucleic acid probesensitive detection

Identifiers

PMID29104223
PMCPMC6150203
OpenAlexW2766948392

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.