ArticleExperimental neurology2018
Newfound sex differences in axonal structure underlie differential outcomes from in vitro traumatic axonal injury.
Article in Experimental neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 4 of them syntheses that pooled it.
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Who cites it
47 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Using neuroimaging to identify sex differences in adults with sports-related concussion: a systematic review.Brain imaging and behavior · 2025Pooled it
- The Incidence, Cost, and Burden of Concussion in Women's Rugby League and Rugby Union: A Systematic Review and Pooled Analysis.Sports medicine (Auckland, N.Z.) · 2022Pooled it
- Association between single moderate to severe traumatic brain injury and long-term tauopathy in humans and preclinical animal models: a systematic narrative review of the literature.Acta neuropathologica communications · 2022Pooled it
- Diffusion MRI as a complementary assessment to cognition, emotion, and motor dysfunction after sports-related concussion: a systematic review and critical appraisal of the literature.Brain imaging and behavior · 2021Pooled it
- Reduced Cerebral Blood Flow in the Early Chronic Phase of Recurrent Concussion Among Female Collegiate-Aged Athletes.Human brain mapping · 2026Article
- Brain regional susceptibility to tauopathy in individuals at risk for chronic traumatic encephalopathy.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- A model of axonal damage accumulation from real-world head impact exposure.Annals of biomedical engineering · 2026Article
- Head Acceleration Events Measured by Instrumented Mouthguards in Elite Australian Football.Sports medicine - open · 2026Article
- Sex-specific hippocampal microstructural alterations in 11-12-year-old adolescents with a history of mild traumatic brain injury.Frontiers in behavioral neuroscience · 2026Article
- MRI investigation of orientation-dependent changes in microstructure and function in a mouse model of mild traumatic brain injury.Acta neuropathologica communications · 2025Article
- Association Between Acute Plasma Glial Fibrillary Acidic Protein Levels and White Matter Integrity in Recent Trauma Survivors.Journal of neurotrauma · 2025Article
- Article
- Self-reported concussion prevalence, post-injury help-seeking behaviour, and associated risk factors among volleyball players.PloS one · 2025Article
- Sex differences in the extent of acute axonal pathologies after experimental concussion.Acta neuropathologica · 2024Article
- Female RNA concussion (FeRNAC) study: assessing hormone profiles and salivary RNA in females with concussion by emergency departments in New Zealand: a study protocol.BMC neurology · 2024Article
- Cognition and post-concussive symptom status after pediatric mild traumatic brain injury.Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence · 2024Article
- Neuroprotection or Sex Bias: A Protective Response to Traumatic Brain Injury in the Females.CNS & neurological disorders drug targets · 2024Review
- ENIGMA's simple seven: Recommendations to enhance the reproducibility of resting-state fMRI in traumatic brain injury.NeuroImage. Clinical · 2024Review
- Unexpected gender differences in progressive supranuclear palsy reveal efficacy for davunetide in women.Translational psychiatry · 2023Article
- Association Between Serum Neurofilament Light and Glial Fibrillary Acidic Protein Levels and Head Impact Burden in Women's Collegiate Water Polo.Journal of neurotrauma · 2023Observational
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Since traumatic axonal injury (TAI) is implicated as a prominent pathology of concussion, we examined potential sex differences in axon structure and responses to TAI. Rat and human neurons were used to develop micropatterned axon tracts in vitro that were genetically either male or female. Ultrastructural analysis revealed for the first time that female axons were consistently smaller with fewer microtubules than male axons. Computational modeling of TAI showed that these structural differences place microtubules in female axons at greater risk of failure during trauma under the same applied loads than in male axons. Likewise, in an in vitro model of TAI, dynamic stretch-injury to axon tracts induced greater pathophysiology of female axons than male axons, including more extensive undulation formations resulting from mechanical breaking of microtubules, and greater calcium influx shortly after the same level of injury. At 24h post-injury, female axons exhibited significantly more swellings and greater loss of calcium signaling function than male axons. Accordingly, sexual dimorphism of axon structure in the brain may also contribute to more extensive axonal pathology in females compared to males exposed to the same mechanical injury.
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