Evidence map›Paper›PMID 29104089›Full record

ArticleClinical immunology (Orlando, Fla.)2018

RAG deficiency with ALPS features successfully treated with TCRαβ/CD19 cell depleted haploidentical stem cell transplant.

Emma Westermann-Clark, Alice Grossi, Francesca Fioredda, Stefano Giardino, Enrico Cappelli, Paola Terranova, Elena Palmisani, Jocelyn R Farmer, Zsofia Foldvari, Yasuhiro Yamazaki and 7 more

Abstract readCase Reports
In one paragraph

Article in Clinical immunology (Orlando, Fla.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  7. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Emma Westermann-ClarkUniversity of South Florida Morsani College of Medicine, Department of Internal Medicine, Division of Allergy/Immunology, Tampa, FL, USA.
Alice GrossiMedical Genetics Unit, Istituto Giannina Gaslini, Genoa, Italy.
Francesca FioreddaHematology Unit, Istituto Giannina Gaslini, Genoa, Italy.
Stefano GiardinoStem Cell Transplantation Unit, Istituto Giannina Gaslini, Genoa, Italy.
Enrico CappelliHematology Unit, Istituto Giannina Gaslini, Genoa, Italy.
Paola TerranovaHematology Unit, Istituto Giannina Gaslini, Genoa, Italy.
Elena PalmisaniHematology Unit, Istituto Giannina Gaslini, Genoa, Italy.
Jocelyn R FarmerDepartment of Allergy & Immunology, Massachusetts General Hospital, Boston, MA, USA.
Zsofia FoldvariDepartment of Cancer Immunology, Oslo University Hospital Radiumhospitalet, Oslo, Norway.
Yasuhiro YamazakiLaboratory of Clinical Immunology and Microbiology, NIAID, National Institutes of Health, Bethesda, MD, USA.
Maura FaraciStem Cell Transplantation Unit, Istituto Giannina Gaslini, Genoa, Italy.
Edoardo LaninoStem Cell Transplantation Unit, Istituto Giannina Gaslini, Genoa, Italy.
Luigi D NotarangeloLaboratory of Clinical Immunology and Microbiology, NIAID, National Institutes of Health, Bethesda, MD, USA.
Carlo DufourHematology Unit, Istituto Giannina Gaslini, Genoa, Italy.
Isabella CeccheriniMedical Genetics Unit, Istituto Giannina Gaslini, Genoa, Italy.
Jolan E WalterUniversity of South Florida at Johns Hopkins All Children's Hospital, Division of Pediatric Allergy/Immunology, St. Petersburg, FL, USA; Division of Pediatric Allergy and Immunology, Massachusetts General Hospital for Children, Boston, MA, USA. Electronic address: jolanwalter@health.usf.edu.
Maurizio MianoHematology Unit, Istituto Giannina Gaslini, Genoa, Italy. Electronic address: mauriziomiano@gaslini.org.

Funding

Characterization of the cellular and molecular bases of inborn errors of immunityZIAAI001222 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI NOTARANGELO, LUIGI · 2017 to 2025
$15.2M
Modeling and correcting human SCID using patient-derived iPS cellsR01AI100887 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI MANIS, JOHN P · 2012 to 2020
$4.5M
Autoimmunity in Rag Deficiency: A Nexus of Immunodeficiency and DysregulationK08AI103035 · NIAID · UNIVERSITY OF SOUTH FLORIDA · PI WALTER, JOLAN ESZTER · 2012 to 2016
$683k
NIAID NIH HHS K08 AI103035NIAID NIH HHS R01 AI100887
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Anemia, Hemolytic, AutoimmuneAntigens, CD19Autoimmune Lymphoproliferative SyndromeChild, PreschoolCytomegalovirus InfectionsHematopoietic Stem Cell MobilizationHomeodomain ProteinsHumansImmunologic Deficiency SyndromesMaleReceptors, Antigen, T-Cell, alpha-betaStem Cell TransplantationTransplantation ConditioningTransplantation, HaploidenticalAntigens, CD19Homeodomain ProteinsRAG-1 proteinReceptors, Antigen, T-Cell, alpha-betaALPSAnti-cytokine autoantibodiesAutoimmune cytopeniaHypomorphic RAG mutationViral infection

Identifiers

PMID29104089
PMCPMC5941932

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.