Evidence map›Paper›PMID 29103990›Full record

ReviewTrends in microbiology2018

A Call to Arms: Quest for a Cryptococcal Vaccine.

Marley C Caballero Van Dyke, Floyd L Wormley

Open access · greenAbstract readReview
In one paragraph

Review in Trends in microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 68 citations in OpenAlex.

  1. Review
  2. Review
  3. Insights from Mass Spectrometry-Based Proteomics onJournal of fungi (Basel, Switzerland) · 2025
    Review
  4. Article
  5. mBio · 2024
    Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. A consensus structural motif for the capsular polysaccharide ofProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  11. Article
  12. Semi-synthetic glycoconjugate vaccine candidate againstbioRxiv : the preprint server for biology · 2024
    Article
  13. Article
  14. Chitosan-Deficient Cryptococcus as Whole-Cell Vaccines.Methods in molecular biology (Clifton, N.J.) · 2024
    Article
  15. Dendritic Cells: Multifunctional Roles in Host Defenses toJournal of fungi (Basel, Switzerland) · 2023
    Review
  16. Article
  17. Review
  18. Vaccination with aInfection and immunity · 2023
    Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Marley C Caballero Van DykeDepartment of Biology, The University of Texas at San Antonio, San Antonio, TX, USA; The South Texas Center for Emerging Infectious Diseases, The University of Texas at San Antonio, San Antonio, TX, USA.
Floyd L WormleyDepartment of Biology, The University of Texas at San Antonio, San Antonio, TX, USA; The South Texas Center for Emerging Infectious Diseases, The University of Texas at San Antonio, San Antonio, TX, USA. Electronic address: floyd.wormley@utsa.edu.
Texas Center for Infectious Disease · USThe University of Texas at San Antonio · US

Funding

UTSA RISE Research Training ProgramR25GM060655 · NIGMS · UNIVERSITY OF TEXAS SAN ANTONIO · PI BAREA-RODRIGUEZ, EDWIN J · 2000 to 2022
$21.6M
Protective Host Immunity Against Pulmonary CryptococcosisR01AI071752 · NIAID · UNIVERSITY OF TEXAS SAN ANTONIO · PI WORMLEY, FLOYD L. · 2007 to 2018
$3.7M
NIAID NIH HHS R01 AI071752NIGMS NIH HHS R25 GM060655
6 · The paper itself

Abstract

Cryptococcosis remains a significant cause of morbidity and mortality world-wide, particularly among AIDS patients. Yet, to date, there are no licensed vaccines clinically available to treat or prevent cryptococcosis. In this review, we provide a rationale to support continued investment in Cryptococcus vaccine research, potential challenges that must be overcome along the way, and a literature review of the current progress underway towards developing a vaccine to prevent cryptococcosis.

Indexed as

Fungal VaccinesAnimalsAntigens, FungalCryptococcosisCryptococcus gattiiCryptococcus neoformansDisease Models, AnimalFungal ProteinsGlycolipidsHumansRecombinant ProteinsVaccinationVaccines, AttenuatedVaccines, InactivatedVaccines, SyntheticAntigens, FungalFungal ProteinsFungal VaccinesGlycolipidsRecombinant ProteinsVaccines, AttenuatedVaccines, InactivatedVaccines, Syntheticcryptococcal vaccinecryptococcosisCryptococcusCryptococcus gattiiCryptococcus neoformans

Identifiers

PMID29103990
PMCPMC5910246
OpenAlexW2766300617

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.