Evidence map›Paper›PMID 29103961›Full record

ArticleAmerican journal of ophthalmology2018

High-resolution Imaging in Male Germ Cell-Associated Kinase (MAK)-related Retinal Degeneration.

Young Ju Lew, Nicholas Rinella, Jia Qin, Joanna Chiang, Anthony T Moore, Travis C Porco, Austin Roorda, Jacque L Duncan

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of ophthalmology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Young Ju LewDepartment of Ophthalmology, University of California, San Francisco, San Francisco, California.
Nicholas RinellaDepartment of Ophthalmology, University of California, San Francisco, San Francisco, California.
Jia QinDepartment of Ophthalmology, University of California, San Francisco, San Francisco, California.
Joanna ChiangDepartment of Ophthalmology, University of California, San Francisco, San Francisco, California.
Anthony T MooreDepartment of Ophthalmology, University of California, San Francisco, San Francisco, California.
Travis C PorcoDepartment of Ophthalmology, University of California, San Francisco, San Francisco, California; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California; Proctor Foundation, University of California, San Francisco, San Francisco, California.
Austin RoordaSchool of Optometry and Vision Science Graduate Group, University of California, Berkeley, Berkeley, California.
Jacque L DuncanDepartment of Ophthalmology, University of California, San Francisco, San Francisco, California. Electronic address: jacque.duncan@ucsf.edu.
University of California, San Francisco · USUniversity of California, Berkeley · US

Funding

Rapid-Prototyping and Design CoreP30EY002162 · NEI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LAKKARAJU, APARNA · 1985 to 2024
$16.8M
Advanced Technology to Study Visual Function on a Cellular ScaleR01EY023591 · NEI · UNIVERSITY OF CALIFORNIA BERKELEY · PI DUNCAN, JACQUE LYNNE, ROORDA, AUSTIN · 2014 to 2023
$11.2M
Structure and Function of the Chorioretinal Complex in Age-Related Macular DegeneR01EY024239 · NEI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI WERNER, JOHN S · 2014 to 2018
$2.4M
NEI NIH HHS P30 EY002162NEI NIH HHS R01 EY023591NEI NIH HHS R01 EY024239
6 · The paper itself

Abstract

purposeTo describe the characteristics of MAK-related retinal degeneration using optical coherence tomography angiography (OCTA) and adaptive optics scanning laser ophthalmoscopy (AOSLO).

designCross-sectional study.

methodsSix patients with rod-cone degeneration and disease-causing mutations in MAK were evaluated with visual acuity, spectral-domain OCT, confocal AOSLO, and OCTA. Foveal avascular zone (FAZ) area, vessel densities, and perfusion densities of the superficial capillary plexus (SCP) and deep capillary plexus (DCP) in the central macula in all 6 patients were compared with 5 normal subjects. Cone spacing was measured in 4 patients from AOSLO images and compared with 37 normal subjects.

resultsPatients ranged from 25 to 81 years of age (mean, 52 years). Visual acuity varied from 20/13 to 20/40

conclusionsAlthough retinal vascular densities are reduced and cone spacing is increased in advanced disease, central foveal structure is maintained until late stages of disease, which may contribute to preservation of foveal vision in eyes with MAK-related retinal degeneration.

Indexed as

Image Processing, Computer-AssistedMutationAdultAgedAged, 80 and overCross-Sectional StudiesDNADNA Mutational AnalysisFemaleFluorescein AngiographyFovea CentralisFundus OculiHumansIntracellular Signaling Peptides and ProteinsMaleMiddle AgedDNAHASPIN protein, humanIntracellular Signaling Peptides and ProteinsProtein Serine-Threonine Kinases

Identifiers

PMID29103961
PMCPMC5732075
OpenAlexW2765892687

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.