Evidence map›Paper›PMID 29103953›Full record

ArticleDevelopmental cell2017

WNT-Mediated Regulation of FOXO1 Constitutes a Critical Axis Maintaining Pubertal Mammary Stem Cell Homeostasis.

Amulya Sreekumar, Michael J Toneff, Eajer Toh, Kevin Roarty, Chad J Creighton, George K Belka, Dong-Kee Lee, Jianming Xu, Lewis A Chodosh, JoAnne S Richards and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Developmental cell, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 49 citations in OpenAlex.

  1. Review
  2. Review
  3. The Yin-Yang of Stress and Senescence: Integrated Stress Response and SASP Crosstalk in Stem Cell Fate, Regeneration, and Disease.Biocell : official journal of the Sociedades Latinoamericanas de Microscopia Electronica ... et. al · 2026
    Article
  4. Article
  5. Review
  6. The dynamics of tubulogenesis in development and disease.Development (Cambridge, England) · 2025
    Review
  7. Rat Models of Breast Cancer.Advances in experimental medicine and biology · 2025
    Review
  8. Article
  9. Article
  10. Article
  11. FOXOs: masters of the equilibrium.The FEBS journal · 2022
    Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Article
  18. Article
  19. The Cellular Organization of the Mammary Gland: Insights From Microscopy.Journal of mammary gland biology and neoplasia · 2021
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Amulya SreekumarDepartment of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.
Michael J ToneffDepartment of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.
Eajer TohDepartment of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.
Kevin RoartyDepartment of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.
Chad J CreightonDepartment of Medicine and Dan L. Duncan Cancer Center Division of Biostatistics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.
George K BelkaDepartment of Cancer Biology, University of Pennsylvania, 421 Curie Boulevard, Philadelphia, PA 19104, USA; Abramson Family Cancer Research Institute, University of Pennsylvania, 421 Curie Boulevard, Philadelphia, PA 19104, USA.
Dong-Kee LeeDepartment of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.
Jianming XuDepartment of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.
Lewis A ChodoshDepartment of Cancer Biology, University of Pennsylvania, 421 Curie Boulevard, Philadelphia, PA 19104, USA; Abramson Family Cancer Research Institute, University of Pennsylvania, 421 Curie Boulevard, Philadelphia, PA 19104, USA; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, 421 Curie Boulevard, Philadelphia, PA 19104, USA.
JoAnne S RichardsDepartment of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.
Jeffrey M RosenDepartment of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA. Electronic address: jrosen@bcm.edu.
Baylor College of Medicine · USCancer Research Institute · US

Funding

Tumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI Michael M Ittmann · 2007 to 2026
$73.9M
Tissue Analysis & Molecular Imaging CoreP30DK056338 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI James Versalovic · 2001 to 2026
$28.3M
Virology CoreP30AI036211 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI SHEARER, WILLIAM THOMAS · 1994 to 2015
$21.7M
Research Education and Career Horizons ProgramK12GM084897 · NIGMS · BAYLOR COLLEGE OF MEDICINE · PI SIFERS, RICHARD NORMAN, SLAUGHTER, GAYLE · 2008 to 2016
$8.3M
MALAT1 lncRNA as a Therapeutic Target in Triple Negative Breast CancerR01CA016303 · NCI · BAYLOR COLLEGE OF MEDICINE · PI ROSEN, JEFFREY MARK · 1985 to 2022
$8.1M
HORMONAL REGULATION OF BREAST CANCERR37CA016303 · NCI · BAYLOR COLLEGE OF MEDICINE · PI ROSEN, JEFFREY MARK · 1989 to 2011
$7.3M
The Role of SRC-1 in Breast CancerR01CA112403 · NCI · BAYLOR COLLEGE OF MEDICINE · PI XU, JIANMING · 2006 to 2016
$2.9M
NCOA6, A Novel Tumor Suppressor of Endometrial CancerR01CA193455 · NCI · BAYLOR COLLEGE OF MEDICINE · PI XU, JIANMING · 2016 to 2021
$1.9M
BD Biosciences Special Order LSRIIS10RR024574 · NCRR · BAYLOR COLLEGE OF MEDICINE · PI LUMPKIN, ELLEN A · 2009 to 2009
$430k
NCI NIH HHS P30 CA125123NCI NIH HHS R01 CA016303NCI NIH HHS R01 CA112403NCI NIH HHS R01 CA193455NCI NIH HHS R37 CA016303NCRR NIH HHS S10 RR024574NIAID NIH HHS P30 AI036211NIDDK NIH HHS P30 DK056338NIGMS NIH HHS K12 GM084897
6 · The paper itself

Abstract

Puberty is characterized by dynamic tissue remodeling in the mammary gland involving ductal elongation, resolution into the mature epithelial bilayer, and lumen formation. To decipher the cellular mechanisms underlying these processes, we studied the fate of putative stem cells, termed cap cells, present in terminal end buds of pubertal mice. Employing a p63

Indexed as

AnimalsApoptosisBreastCell LineageCell ProliferationForkhead Box Protein O1HomeostasisMammary Glands, AnimalMice, TransgenicStem CellsWnt Signaling PathwayForkhead Box Protein O1Foxo1 protein, mouseapoptosiscap cellsFOXO transcription factorsmammary stem cellsp63 lineage tracingWNT pathway

Identifiers

PMID29103953
PMCPMC5698144
OpenAlexW2765509001

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.