ArticleCell metabolism2018
17β-Estradiol Directly Lowers Mitochondrial Membrane Microviscosity and Improves Bioenergetic Function in Skeletal Muscle.
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Article in Cell metabolism, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 104 papers.
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104citing papers in PubMed
8.4field-weighted citation impact, top 2% of its field
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104 citing papers in PubMed, 170 citations in OpenAlex.
- Muscle mitochondrial capacity in high- and low-fitness females using near-infrared spectroscopy.Physiological reports · 2021Trial
- Ovarian hormone loss modifies the nucleic acid cargo of circulating extracellular vesicles and skeletal muscle metabolism after acute exercise in rats.Experimental physiology · 2026Article
- 17β-Estradiol mitigates ovariectomy-induced defects in mitochondrial bioenergetics and redox balance after VML injury in female mice.American journal of physiology. Cell physiology · 2026Article
- TAK1 Regulates Skeletal Muscle Mass, Hypertrophic Signaling, and Metabolic Homeostasis in Male and Female Mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Innovative mitochondria-based holistic 3PM approach to female health status: Facts and outlook.The EPMA journal · 2026Article
- TAK1 regulates skeletal muscle mass, hypertrophic signaling, and metabolic homeostasis in male and female mice.bioRxiv : the preprint server for biology · 2026Article
- Association of mitochondrial oxidative capacity with physical fitness in ageing: the Baltimore longitudinal study of ageing.Age and ageing · 2026Article
- Effects of Voluntary Exercise and Acetic Acid Supplementation on Skeletal Muscle Mitochondrial Function in Ovariectomized Mice.Nutrients · 2026Article
- The Role and Mechanism of Estrogen in Perimenopausal Depression.Current neuropharmacology · 2026Review
- Intraperitoneal Administration of Cardiolipin Enhances Mitochondrial Respiration in Skeletal Muscle of Male Mice.Journal of experimental pharmacology · 2026Article
- Unveiling the nanotoxicology of snake venoms through functional and biochemical characterization of extracellular vesicles from Naja naja and Daboia russelii.Scientific reports · 2025Article
- Exercise-induced mitochondrial protection in skeletal muscle of ovariectomized mice: A myogenic ERedox biology · 2025Article
- Sex differences in resting skeletal muscle and the acute and long-term response to endurance exercise in individuals with overweight and obesity.Molecular metabolism · 2025Article
- Sex hormone-binding globulin controls sex-specific lipolytic activity in human abdominal subcutaneous adipocytes.Molecular metabolism · 2025Article
- Menstrual cycle influence on skeletal muscle mitochondrial respiration in humans.Physiological reports · 2025Article
- Loss of ovarian function prevents exercise-induced activation of hepatic mitophagic flux.American journal of physiology. Endocrinology and metabolism · 2025Article
- Metabolic Messengers: oestradiol.Nature metabolism · 2025Review
- The acute exercise response of peripheral blood mononuclear cells and their bioenergetic function in women with high and low systemic estradiol levels.Physiological reports · 2025Article
- An investigation into the sex dependence of post-reperfusion cardiac mitochondrial function and redox balance in chronically stressed rats.Physiological reports · 2025Article
- Inflammaging: triggers, molecular mechanisms, immunological consequences, sex differences, and cutaneous manifestations.Frontiers in immunology · 2025Review
44 more citing papers are in PubMed but not listed here.
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Authors and funding
15 authors at 2 institutions in 1 country.
Maria J TorresEast Carolina Diabetes and Obesity Institute, East Carolina University, 115 Heart Drive, ECHI - Mail Stop 743, Greenville, NC 27834, USA; Department of Kinesiology, College of Health and Human Performance, East Carolina University, Greenville, NC 27834, USA.
Kim A KewDepartment of Chemistry, College of Arts and Sciences, East Carolina University, Greenville, NC 27834, USA.
Terence E RyanEast Carolina Diabetes and Obesity Institute, East Carolina University, 115 Heart Drive, ECHI - Mail Stop 743, Greenville, NC 27834, USA; Department of Physiology, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA.
Edward Ross PenningtonEast Carolina Diabetes and Obesity Institute, East Carolina University, 115 Heart Drive, ECHI - Mail Stop 743, Greenville, NC 27834, USA; Department of Biochemistry and Molecular Biology, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA.
Chien-Te LinEast Carolina Diabetes and Obesity Institute, East Carolina University, 115 Heart Drive, ECHI - Mail Stop 743, Greenville, NC 27834, USA; Department of Physiology, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA.
Katherine A BuddoDepartment of Chemistry, College of Arts and Sciences, East Carolina University, Greenville, NC 27834, USA.
Amy M FixEast Carolina Diabetes and Obesity Institute, East Carolina University, 115 Heart Drive, ECHI - Mail Stop 743, Greenville, NC 27834, USA.
Cheryl A SmithEast Carolina Diabetes and Obesity Institute, East Carolina University, 115 Heart Drive, ECHI - Mail Stop 743, Greenville, NC 27834, USA; Department of Physiology, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA.
Laura A GilliamEast Carolina Diabetes and Obesity Institute, East Carolina University, 115 Heart Drive, ECHI - Mail Stop 743, Greenville, NC 27834, USA; Department of Physiology, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA.
Sira KarvinenDivisions of Rehabilitation Science and Physical Therapy, Department of Rehabilitation Medicine, Medical School, University of Minnesota, Minneapolis, MN 55455, USA.
Dawn A LoweDivisions of Rehabilitation Science and Physical Therapy, Department of Rehabilitation Medicine, Medical School, University of Minnesota, Minneapolis, MN 55455, USA.
Espen E SpangenburgEast Carolina Diabetes and Obesity Institute, East Carolina University, 115 Heart Drive, ECHI - Mail Stop 743, Greenville, NC 27834, USA; Department of Physiology, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA.
Tonya N ZeczyckiEast Carolina Diabetes and Obesity Institute, East Carolina University, 115 Heart Drive, ECHI - Mail Stop 743, Greenville, NC 27834, USA; Department of Biochemistry and Molecular Biology, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA.
Saame Raza ShaikhEast Carolina Diabetes and Obesity Institute, East Carolina University, 115 Heart Drive, ECHI - Mail Stop 743, Greenville, NC 27834, USA; Department of Biochemistry and Molecular Biology, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA.
P Darrell NeuferEast Carolina Diabetes and Obesity Institute, East Carolina University, 115 Heart Drive, ECHI - Mail Stop 743, Greenville, NC 27834, USA; Department of Kinesiology, College of Health and Human Performance, East Carolina University, Greenville, NC 27834, USA; Department of Physiology, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA. Electronic address: neuferp@ecu.edu.
East Carolina University · USUniversity of Minnesota Medical Center · US
Funding
Interatction of Estrogen, Age and Activity on Musculoskeletal Strength in FemalesR01AG031743 · NIA · UNIVERSITY OF MINNESOTA · PI DAWN A LOWE · 2009 to 2026
$7.4MSuppressing inflammation and boosting humoral immunity with n-3 PUFAsR01AT008375 · NCCIH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SHAIKH, SAAME R · 2015 to 2019
$1.9MImpact of organic cations on mitochondrial energetic driving forces and metabolic efficiencyR01DK110656 · NIDDK · EAST CAROLINA UNIVERSITY · PI NEUFER, P DARRELL · 2016 to 2019
$1.8MRedox Biology and Muscle Insulin SensitivityR01DK096907 · NIDDK · EAST CAROLINA UNIVERSITY · PI NEUFER, P DARRELL · 2012 to 2015
$1.4MMitochondrial respirasomes in acute coronary syndromesR01HL123647 · NHLBI · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI HULVER, MATTHEW W, SHAIKH, SAAME R · 2015 to 2018
$1.4MNCCIH NIH HHS R01 AT008375NHLBI NIH HHS R01 HL123647NIA NIH HHS R01 AG031743NIDDK NIH HHS R01 DK096907NIDDK NIH HHS R01 DK110656
Abstract
Menopause results in a progressive decline in 17β-estradiol (E2) levels, increased adiposity, decreased insulin sensitivity, and a higher risk for type 2 diabetes. Estrogen therapies can help reverse these effects, but the mechanism(s) by which E2 modulates susceptibility to metabolic disease is not well understood. In young C57BL/6N mice, short-term ovariectomy decreased-whereas E2 therapy restored-mitochondrial respiratory function, cellular redox state (GSH/GSSG), and insulin sensitivity in skeletal muscle. E2 was detected by liquid chromatography-mass spectrometry in mitochondrial membranes and varied according to whole-body E2 status independently of ERα. Loss of E2 increased mitochondrial membrane microviscosity and H
Indexed as
Energy MetabolismAdiposityAnimalsCell RespirationCellular MicroenvironmentDiabetes Mellitus, ExperimentalElectron TransportElectron Transport Complex IEstradiolFemaleGlucoseHomeostasisMice, Inbred C57BLMitochondriaMitochondrial MembranesMuscle, SkeletalElectron Transport Complex IEstradiolGlucoseestrogenhormone replacement therapyhydrogen peroxideinsulin resistancemembrane viscositymenopausemitochondriaovariectomy
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