ArticleExtremophiles : life under extreme conditions2018
An anti-HBV anthraquinone from aciduric fungus Penicillium sp. OUCMDZ-4736 under low pH stress.
Article in Extremophiles : life under extreme conditions, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 35 citations in OpenAlex.
- Chemical Constituents of Deep-Sea-Derived Fungus Penicillium citrinum W17 and Their Ferroptosis Inhibitory Activity.Chemistry & biodiversity · 2026Article
- Fungal Stress Responses and the Importance of GPCRs.Journal of fungi (Basel, Switzerland) · 2025Review
- Structurally Diverse New Metabolites from Three Hadal Trench-Derived Microorganisms.ACS omega · 2025Article
- Effects of Marine Natural Products on Liver Diseases.Marine drugs · 2024Review
- Marine-Derived Bioactive Metabolites as a Potential Therapeutic Intervention in Managing Viral Diseases: Insights from the SARS-CoV-2 In Silico and Pre-Clinical Studies.Pharmaceuticals (Basel, Switzerland) · 2024Review
- Carneusones A-F, Benzophenone Derivatives from Sponge-Derived FungusMarine drugs · 2024Article
- The First Description of the Microbial Diversity in the Amarillo River (La Rioja, Argentina), a Natural Extreme Environment Where the Whole Microbial Community Paints the Landscape Yellow.Microorganisms · 2024Article
- Anthraquinones and Their Analogues from Marine-Derived Fungi: Chemistry and Biological Activities.Marine drugs · 2022Review
- Microbial Natural Products with Antiviral Activities, Including Anti-SARS-CoV-2: A Review.Molecules (Basel, Switzerland) · 2022Review
- Mono- and Dimeric Xanthones with Anti-Glioma and Anti-Inflammatory Activities from the Ascidian-Derived FungusMarine drugs · 2022Article
- Microbial Metabolites: The Emerging Hotspot of Antiviral Compounds as Potential Candidates to Avert Viral Pandemic Alike COVID-19.Frontiers in molecular biosciences · 2021Review
- Recent progresses in marine microbial-derived antiviral natural products.Archives of pharmacal research · 2020Review
- Fungal Bioactive Anthraquinones and Analogues.Toxins · 2020Review
- Bioactive Metabolites From Acid-Tolerant Fungi in a Thai Mangrove Sediment.Frontiers in microbiology · 2020Article
- Polyketides From the Endophytic FungusFrontiers in chemistry · 2018Article
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Authors and funding
7 authors at 2 institutions in 1 country.
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Abstract
To obtain new bioactive natural products, the effect of acidic stress on the metabolites of an aciduric fungus was investigated. This fungus, Penicillium sp. OUCMDZ-4736, which was isolated from the sediment around roots of mangrove (Acanthus ilicifolius), produced different compounds and higher yields under pH 2.5 than under neutral conditions. Using spectroscopic analyses and calculations, three new anthraquinone derivatives (1-3) were isolated and identified from the acidic fermentation broth (pH 2.5) of OUCMDZ-4736. Compound 1 showed much stronger anti-hepatitis B virus activity than that of the positive control, lamivudine, strongly inhibiting HBsAg and HBeAg secretion from HepG2.2.15 cells. These results show that extremophiles are a valuable resource of bioactive compounds, and that pH regulation is an effective strategy to induce metabolite production in aciduric fungi.
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