Evidence map›Paper›PMID 29103146›Full record

ArticleCellular and molecular life sciences : CMLS2018

RNA cytosine methyltransferase Nsun3 regulates embryonic stem cell differentiation by promoting mitochondrial activity.

Lukas Trixl, Thomas Amort, Alexandra Wille, Manuela Zinni, Susanne Ebner, Clara Hechenberger, Felix Eichin, Hanna Gabriel, Ines Schoberleitner, Anming Huang and 4 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 87 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Lukas TrixlDivision of Molecular Biology, Biocenter, Medical University of Innsbruck, Innrain 80-82, 6020, Innsbruck, Austria.
Thomas AmortDivision of Molecular Biology, Biocenter, Medical University of Innsbruck, Innrain 80-82, 6020, Innsbruck, Austria.
Alexandra WilleDivision of Molecular Biology, Biocenter, Medical University of Innsbruck, Innrain 80-82, 6020, Innsbruck, Austria.
Manuela ZinniDivision of Molecular Biology, Biocenter, Medical University of Innsbruck, Innrain 80-82, 6020, Innsbruck, Austria.
Susanne EbnerDaniel Swarovski Research Laboratory, Department of Visceral, Transplant, and Thoracic Surgery, Medical University of Innsbruck, 6020, Innsbruck, Austria.
Clara HechenbergerDivision of Molecular Biology, Biocenter, Medical University of Innsbruck, Innrain 80-82, 6020, Innsbruck, Austria.
Felix EichinDivision of Molecular Biology, Biocenter, Medical University of Innsbruck, Innrain 80-82, 6020, Innsbruck, Austria.
Hanna GabrielDivision of Molecular Biology, Biocenter, Medical University of Innsbruck, Innrain 80-82, 6020, Innsbruck, Austria.
Ines SchoberleitnerDivision of Molecular Biology, Biocenter, Medical University of Innsbruck, Innrain 80-82, 6020, Innsbruck, Austria.
Anming HuangDivision of Molecular Biology, Biocenter, Medical University of Innsbruck, Innrain 80-82, 6020, Innsbruck, Austria.
Paolo PiattiZymo Research Corp., Irvine, CA, USA.
Roxana NatInstitute for Neuroscience, Medical University of Innsbruck, 6020, Innsbruck, Austria.
Jakob TroppmairDaniel Swarovski Research Laboratory, Department of Visceral, Transplant, and Thoracic Surgery, Medical University of Innsbruck, 6020, Innsbruck, Austria.
Alexandra LusserDivision of Molecular Biology, Biocenter, Medical University of Innsbruck, Innrain 80-82, 6020, Innsbruck, Austria. alexandra.lusser@i-med.ac.at.ORCID 0000-0002-2226-9081
Innsbruck Medical University · AT

Funding

Austrian Science Fund P27024-BBLAustrian Science Fund FWF P 27024
6 · The paper itself

Abstract

Chemical modifications of RNA have been attracting increasing interest because of their impact on RNA fate and function. Therefore, the characterization of enzymes catalyzing such modifications is of great importance. The RNA cytosine methyltransferase NSUN3 was recently shown to generate 5-methylcytosine in the anticodon loop of mitochondrial tRNA

Indexed as

5-MethylcytosineAnimalsCell DifferentiationCell LineEmbryoid BodiesGene Expression Regulation, DevelopmentalGenes, ReporterGreen Fluorescent ProteinsMethyltransferasesMiceMitochondriaMouse Embryonic Stem CellsNeural PlateOxidative PhosphorylationReactive Oxygen SpeciesRNA, Transfer, Met5-Methylcytosineenhanced green fluorescent proteinGreen Fluorescent ProteinsMethyltransferasesReactive Oxygen SpeciesRNA, Transfer, Met5-MethylcytosineBisulfite sequencingEpitranscriptomeMitochondriaNeuroectodermSelf-renewaltRNA modification

Identifiers

PMID29103146
PMCPMC5852174
OpenAlexW2766067960

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.