ArticleJournal of Alzheimer's disease : JAD2018
Circulating Progenitor Cells Correlate with Memory, Posterior Cortical Thickness, and Hippocampal Perfusion.
Article in Journal of Alzheimer's disease : JAD, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Circulating Progenitor Cells, Regenerative Capacity and Cognition: Evidence From 2 Community-Based Cohorts.Arteriosclerosis, thrombosis, and vascular biology · 2026Article
- Association of baPWV and CD34Frontiers in cell and developmental biology · 2026Article
- CD34+ Hematopoietic Stem Cell Counts in Alzheimer's Disease: A Meta-Analysis.Diseases (Basel, Switzerland) · 2025Review
- Endothelial progenitor cells and cerebral small vessel disease inCerebral circulation - cognition and behavior · 2025Article
- An Investigation of the Inflammatory Landscape in the Brain and Bone Marrow of the APP/PS1 Mouse.Journal of Alzheimer's disease reports · 2024Article
- Contributions of loneliness to cognitive impairment and dementia in older adults are independent of other risk factors and Alzheimer's pathology: a narrative review.Frontiers in human neuroscience · 2024Review
- Review
- CD34Neural regeneration research · 2023Article
- Circulating endothelial and angiogenic cells predict hippocampal volume as a function of HIV status.Journal of neurovirology · 2023Article
- Role of Endothelial Progenitor Cells in Frailty.International journal of molecular sciences · 2023Review
- Blood-Derived Progenitor Cells Are Depleted in Older Adults with Cognitive Impairment: A Role for Vascular Resilience?Journal of Alzheimer's disease : JAD · 2023Article
- Article
- Associations between increased circulating endothelial progenitor cell levels and anxiety/depressive severity, cognitive deficit and function disability among patients with major depressive disorder.Scientific reports · 2021Article
- Role of Notch signaling in neurovascular aging and Alzheimer's disease.Seminars in cell & developmental biology · 2021Article
- Increased Levels of Circulating Angiogenic Cells and Signaling Proteins in Older Adults With Cerebral Small Vessel Disease.Frontiers in aging neuroscience · 2021Article
- Endothelial Progenitor Cells and Vascular Alterations in Alzheimer's Disease.Frontiers in aging neuroscience · 2021Review
- An update on magnetic resonance imaging markers in AD.Therapeutic advances in neurological disorders · 2020Review
- Circulating Progenitor Cells and Cognitive Impairment in Men and Women with Coronary Artery Disease.Journal of Alzheimer's disease : JAD · 2020Article
- A Novel Angiotensin-(1-7) Glycosylated Mas Receptor Agonist for Treating Vascular Cognitive Impairment and Inflammation-Related Memory Dysfunction.The Journal of pharmacology and experimental therapeutics · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
backgroundBone marrow-derived progenitor cells survey the vasculature and home to sites of tissue injury where they can promote repair and regeneration. It has been hypothesized that these cells may play a protective role neurodegenerative and vascular cognitive impairment.
objectiveTo evaluate progenitor cell levels in older adults with and without mild cognitive impairment (MCI), and to relate circulating levels to memory, brain volume, white matter lesion volume, and cerebral perfusion.
methodThirty-two older adults, free of stroke and cardiovascular disease, were recruited from the community and evaluated for diagnosis of MCI versus cognitively normal (CN). Participants underwent brain MRI and blood samples were taken to quantify progenitor reserve using flow cytometry (CD34+, CD34+CD133+, and CD34+CD133+CD309+ cells).
resultsParticipants with MCI (n = 10) exhibited depletion of all CPC markers relative to those who were CN (n = 22), after controlling for age, sex, and education. Post-hoc age, sex, and education matched comparisons (n = 10 MCI, n = 10 CN) also revealed the same pattern of results. Depletion of CD34+ cells correlated with memory performance, left posterior cortical thickness, and bilateral hippocampal perfusion. Participants exhibited low levels of vascular risk and white matter lesion burden that did not correlate with progenitor levels.
conclusionsCirculating progenitor cells are associated with cognitive impairment, memory, cortical atrophy, and hippocampal perfusion. We hypothesize that progenitor depletion contributes to, or is triggered by, cognitive decline and cortical atrophy. Further study of progenitor cell depletion in older adults may benefit efforts to prevent or delay dementia.
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