Evidence map›Paper›PMID 29102983›Full record

ArticleBMJ open2017

Randomised controlled non-inferiority trial of primary care-based facilitated access to an alcohol reduction website: cost-effectiveness analysis.

Rachael Hunter, Paul Wallace, Pierluigi Struzzo, Roberto Della Vedova, Francesca Scafuri, Costanza Tersar, Charilaos Lygidakis, Richard McGregor, Emanuele Scafato, Nick Freemantle

Registry-linked trialAbstract readEquivalence Trial
In one paragraph

Article in BMJ open, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01638338 (Optimizing and Integrating the Delivery of Primary Care Services for Risky Drinkers in Region Friuli-Venezia Giulia), which is not on this map. Cited by 8 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01638338 nacompletednot on this map

Optimizing and Integrating the Delivery of Primary Care Services for Risky Drinkers in Region Friuli-Venezia Giulia

TypeinterventionalSponsorAzienda Per I Servizi Sanitari N. 2 IsontinaRan2012 to 2015Enrolled674ConditionsExcessive DrinkingArmsWeb assisted brief motivational interview on risky drinking, Face to Face
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Digital interventions in mental health: evidence syntheses and economic modelling.Health technology assessment (Winchester, England) · 2022
    Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Trial
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Rachael HunterDepartment of Primary Care and Population Health, University College London, London, UK.ORCID http://orcid.org/0000-0002-7447-8934
Paul WallaceDepartment of Primary Care and Population Health, University College London, London, UK.
Pierluigi StruzzoRegional Centre for Training in Primary Care, Monfalcone, Gorizia, Italy.
Roberto Della VedovaCSeRMEG, Centro Studi e Ricerche in Medicina Generale, Udine, Friuli Venzia Giulia, Italy.
Francesca ScafuriRegional Centre for Training in Primary Care, Monfalcone, Gorizia, Italy.
Costanza TersarDepartment of Life Sciences, University of Trieste, Trieste, Italy.
Charilaos LygidakisResearch Unit INSIDE, Institute for Health and Behaviour, Université du Luxembourg, Luxembourg, Luxembourg.
Richard McGregorCodeface Ltd, Hove, UK.
Emanuele ScafatoIstituto Superiore di Sanità,, WHO Collaborating Centre for Research and Health Promotion on Alcohol and Alcohol-Related Health Problems, Roma, Lazio, Italy.
Nick FreemantleDepartment of Primary Care and Population Health, University College London, London, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo evaluate the 12-month costs and quality-adjusted life years (QALYs) gained to the Italian National Health Service of facilitated access to a website for hazardous drinkers compared with a standard face-to-face brief intervention (BI).

designRandomised 1:1 non-inferiority trial.

settingPractices of 58 general practitioners (GPs) in Italy.

participantsOf 9080 patients (>18 years old) approached to take part in the trial, 4529 (49·9%) logged on to the website and 3841 (84.8%) undertook online screening for hazardous drinking. 822 (21.4%) screened positive and 763 (19.9%) were recruited to the trial.

interventionsPatients were randomised to receive either a face-to-face BI or access via a brochure from their GP to an alcohol reduction website (facilitated access). PRIMARY AND SECONDARY OUTCOME MEASURES: The primary outcome is the cost per QALY gained of facilitated access compared with face-to-face. A secondary analysis includes total costs and benefits per 100 patients, including number of hazardous drinkers prevented at 12 months.

resultsThe average time required for the face-to-face BI was 8 min (95% CI 7.5 min to 8.6 min). Given the maximum time taken for facilitated access of 5 min, face-to-face is an additional 3 min: equivalent to having time for another GP appointment for every three patients referred to the website. Complete case analysis adjusting for baseline the difference in QALYs for facilitated access is 0.002 QALYs per patient (95% CI -0.007 to 0.011).

conclusionsFacilitated access to a website to reduce hazardous drinking costs less than a face-to-face BI given by a GP with no worse outcomes. The lower cost of facilitated access, particularly in regards to investment of time, may facilitate the increase in provision of BIs for hazardous drinking. TRIAL REGISTRATION NUMBER: NCT01638338;Post-results.

Indexed as

InternetRisk Reduction BehaviorAdultAlcohol DrinkingCost-Benefit AnalysisFemaleFollow-Up StudiesHumansItalyLinear ModelsMaleMiddle AgedPrimary Health CareQuality of Lifehealth economicsinformation technologysubstance misuseworld wide web technology

Identifiers

PMID29102983
PMCPMC5722092

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.