Evidence map›Paper›PMID 29102818›Full record

Trial reportJournal of anxiety disorders2017

Pharmacotherapy for social anxiety disorder: Interpersonal predictors of outcome and the mediating role of the working alliance.

Jonah N Cohen, Deborah A G Drabick, Carlos Blanco, Franklin R Schneier, Michael R Liebowitz, Richard G Heimberg

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of anxiety disorders, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jonah N CohenDepartment of Psychology, 1701 North 13th Street, Weiss Hall, Temple University, Philadelphia, PA, 19122, USA.
Deborah A G DrabickDepartment of Psychology, 1701 North 13th Street, Weiss Hall, Temple University, Philadelphia, PA, 19122, USA.
Carlos BlancoDepartment of Psychiatry, Columbia University Medical Center, Harkness Pavilion, 180 Ft. Washington Avenue, New York, NY, 10032, USA; New York State Psychiatric Institute, 1051 Riverside Drive, New York, NY, 10032, USA.
Franklin R SchneierDepartment of Psychiatry, Columbia University Medical Center, Harkness Pavilion, 180 Ft. Washington Avenue, New York, NY, 10032, USA; New York State Psychiatric Institute, 1051 Riverside Drive, New York, NY, 10032, USA.
Michael R LiebowitzDepartment of Psychiatry, Columbia University Medical Center, Harkness Pavilion, 180 Ft. Washington Avenue, New York, NY, 10032, USA.
Richard G HeimbergDepartment of Psychology, 1701 North 13th Street, Weiss Hall, Temple University, Philadelphia, PA, 19122, USA. Electronic address: heimberg@temple.edu.

Funding

CBT Augmentation of Paroxetine for Social AnxietyR01MH064726 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI LIEBOWITZ, MICHAEL R. · 2003 to 2006
$1.4M
CBT Augmentation of Paroxetine for Social AnxietyR01MH064481 · NIMH · TEMPLE UNIV OF THE COMMONWEALTH · PI HEIMBERG, RICHARD G · 2003 to 2006
$1.2M
NIMH NIH HHS R01 MH064481NIMH NIH HHS R01 MH064726
6 · The paper itself

Abstract

Social anxiety disorder (SAD) is highly prevalent and associated with high levels of impairment and distress. Therapies for SAD leave many patients symptomatic at the end of treatment, and little is known about predictors or mechanisms of treatment outcome. Given the interpersonal dysfunction fundamental to SAD, this study investigated whether prominent interpersonal features of SAD (submissive behavior, childhood maltreatment, suppression of anger, and depression) predicted attrition and response to pharmacotherapy and whether the working alliance mediated these relationships. This is the first study to examine the role of the working alliance in pharmacotherapy for SAD. One hundred thirty-eight treatment-seeking individuals with a primary diagnosis of SAD received 12 weeks of open treatment with paroxetine. Higher levels of depression predicted greater severity of SAD at the end of treatment, and higher levels of submissive behavior and childhood emotional maltreatment predicted a greater probability of attrition from treatment. The psychiatrist-assessed working alliance mediated response to pharmacotherapy for individuals who reported a history of emotional maltreatment. These results identify variables that predict pharmacotherapy outcome and emphasize the importance of the working alliance as a mechanism of treatment response for those with a history of emotional maltreatment. Implications for person-specific treatment selection are discussed.

Indexed as

AdultAntidepressive Agents, Second-GenerationDepressive DisorderEmotionsFemaleHumansMaleMiddle AgedParoxetinePhobia, SocialTreatment OutcomeAntidepressive Agents, Second-GenerationParoxetineParoxetinePharmacotherapySocial anxiety disorderTreatment mechanismTreatment predictorWorking alliance

Identifiers

PMID29102818
PMCPMC5689479

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.