Evidence map›Paper›PMID 29102700›Full record

ReviewInternational journal of pharmaceutics2018

Melt extrusion with poorly soluble drugs - An integrated review.

Michael A Repka, Suresh Bandari, Venkata Raman Kallakunta, Anh Q Vo, Haley McFall, Manjeet B Pimparade, Ajinkya M Bhagurkar

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of pharmaceutics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers.

0numbers the graph read from it
0cells of the map it votes in
79citing papers in PubMed
10.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

79 citing papers in PubMed, 212 citations in OpenAlex.

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  9. Mechanochemistry: Fundamental Principles and Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
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19 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Michael A RepkaDepartment of Pharmaceutics and Drug Delivery, University of Mississippi, University, MS 38677, USA; Pii Center for Pharmaceutical Technology, University of Mississippi, University, MS 38677, USA. Electronic address: marepka@olemiss.edu.
Suresh BandariDepartment of Pharmaceutics and Drug Delivery, University of Mississippi, University, MS 38677, USA.
Venkata Raman KallakuntaDepartment of Pharmaceutics and Drug Delivery, University of Mississippi, University, MS 38677, USA.
Anh Q VoDepartment of Pharmaceutics and Drug Delivery, University of Mississippi, University, MS 38677, USA.
Haley McFallDepartment of Pharmaceutics and Drug Delivery, University of Mississippi, University, MS 38677, USA.
Manjeet B PimparadeDepartment of Pharmaceutics and Drug Delivery, University of Mississippi, University, MS 38677, USA.
Ajinkya M BhagurkarDepartment of Pharmaceutics and Drug Delivery, University of Mississippi, University, MS 38677, USA.
University of Mississippi · US

Funding

Center of Research Excellence in Natural Products Neuroscience (CORE-NPN)P20GM104932 · NIGMS · UNIVERSITY OF MISSISSIPPI · PI MAJUMDAR, SOUMYAJIT · 2012 to 2016
$10.0M
NIGMS NIH HHS P20 GM104932
6 · The paper itself

Abstract

Over the last few decades, hot melt extrusion (HME) has emerged as a successful technology for a broad spectrum of applications in the pharmaceutical industry. As indicated by multiple publications and patents, HME is mainly used for the enhancement of solubility and bioavailability of poorly soluble drugs. This review is focused on the recent reports on the solubility enhancement via HME and provides an update for the manufacturing/scaling up aspects of melt extrusion. In addition, drug characterization methods and dissolution studies are discussed. The application of process analytical technology (PAT) tools and use of HME as a continuous manufacturing process may shorten the drug development process; as a result, the latter is becoming the most widely utilized technique in the pharmaceutical industry. The advantages, disadvantages, and practical applications of various PAT tools such as near and mid-infrared, ultraviolet/visible, fluorescence, and Raman spectroscopies are summarized, and the characteristics of other techniques are briefly discussed. Overall, this review also provides an outline for the currently marketed products and analyzes the strengths, weaknesses, opportunities and threats of HME application in the pharmaceutical industry.

Indexed as

Drug Delivery SystemsEquipment DesignPharmaceutical PreparationsSolubilityTechnology, PharmaceuticalPharmaceutical PreparationsContinuous manufacturingDissolutionHot melt extrusionPolymerPoorly soluble drugProcess analytical technology toolSWOT analysis

Identifiers

PMID29102700
PMCPMC5756511
OpenAlexW2766983743

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.