Evidence map›Paper›PMID 29102678›Full record

ArticleBiochemical pharmacology2018

A monoclonal antibody raised against a thermo-stabilised β

Mark Soave, Gabriella Cseke, Catherine J Hutchings, Alastair J H Brown, Jeanette Woolard, Stephen J Hill

Open access · hybridAbstract read
In one paragraph

Article in Biochemical pharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Biased activation of βCell death discovery · 2021
    Article
  3. Review
  4. Therapeutic Antibodies Targeting Potassium Ion Channels.Handbook of experimental pharmacology · 2021
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Mark SoaveDivision of Physiology, Pharmacology and Neuroscience, School of Life Sciences, University of Nottingham, Nottingham NG7 2UH, UK; Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham and University of Nottingham, Midlands, UK.
Gabriella CsekeHeptares Therapeutics Ltd., Bio Park, Welwyn Garden City AL7 3AX, UK.
Catherine J HutchingsHeptares Therapeutics Ltd., Bio Park, Welwyn Garden City AL7 3AX, UK.
Alastair J H BrownHeptares Therapeutics Ltd., Bio Park, Welwyn Garden City AL7 3AX, UK.
Jeanette WoolardDivision of Physiology, Pharmacology and Neuroscience, School of Life Sciences, University of Nottingham, Nottingham NG7 2UH, UK; Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham and University of Nottingham, Midlands, UK. Electronic address: jeanette.woolard@nottingham.ac.uk.
Stephen J HillDivision of Physiology, Pharmacology and Neuroscience, School of Life Sciences, University of Nottingham, Nottingham NG7 2UH, UK; Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham and University of Nottingham, Midlands, UK. Electronic address: stephen.hill@nottingham.ac.uk.
Heptares Therapeutics (United Kingdom) · GBUniversity of Birmingham · GBUniversity of Nottingham · GB

Funding

Medical Research Council G0800006Medical Research Council MR/N020081/1
6 · The paper itself

Abstract

Recent interest has focused on antibodies that can discriminate between different receptor conformations. Here we have characterised the effect of a monoclonal antibody (mAb3), raised against a purified thermo-stabilised turkey β

Indexed as

Adrenergic beta-AgonistsAllosteric RegulationAmino Acid SequenceAnimalsAntibodies, MonoclonalCHO CellsCricetinaeCricetulusHEK293 CellsHumansPropanolaminesProtein BindingProtein StabilityProtein Structure, SecondaryReceptors, Adrenergic, beta-1TurkeyAdrenergic beta-AgonistsAntibodies, MonoclonalCGP 12177PropanolaminesReceptors, Adrenergic, beta-1AllosterismAlprenolol (Pubchem CID: 2119)CGP 12177 (Pubchem CID: 2687)CGP 20712A (Pubchem CID: 2685)Cimaterol (Pubchem CID: 2755)Extracellular loop 2Furimazine (Pubchem CID: 219083)GPCRHoechst 33342 (Pubchem CID: 1464)IBMX (Pubchem CID: 3758)ICI 118551 (Pubchem CID: 5484725)Isoprenaline (Pubchem CID: 5807)Monoclonal antibodyPropranolol (Pubchem CID: 4946)

Identifiers

PMID29102678
PMCPMC5770334
OpenAlexW2766376107

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.