Evidence map›Paper›PMID 29102637›Full record

ArticleJournal of hazardous materials2018

Assessment of reactive oxygen species generated by electronic cigarettes using acellular and cellular approaches.

Jiayuan Zhao, Yipei Zhang, Jennifer D Sisler, Justine Shaffer, Stephen S Leonard, Anna M Morris, Yong Qian, Dhimiter Bello, Philip Demokritou

Abstract read
In one paragraph

Article in Journal of hazardous materials, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Lung Damage Caused by Heated Tobacco Products and Electronic Nicotine Delivery Systems: A Systematic Review.International journal of environmental research and public health · 2021
    Pooled it
  3. Pooled it
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. E-Cigarette effects on oral health: A molecular perspective.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2025
    Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
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  18. Article
  19. Influence of puff topographies on e-liquid heating temperature, emission characteristics and modeled lung deposition of Puff BarAerosol science and technology : the journal of the American Association for Aerosol Research · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jiayuan ZhaoDepartment of Environmental Health, Center for Nanotechnology and Nanotoxicology, Harvard School of Public Health, Boston, MA 02115, USA.
Yipei ZhangDepartment of Public Health, University of Massachusetts Lowell, MA 01854, USA.
Jennifer D SislerPathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health (NIOSH), Morgantown, WV 26505, USA.
Justine ShafferPathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health (NIOSH), Morgantown, WV 26505, USA.
Stephen S LeonardPathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health (NIOSH), Morgantown, WV 26505, USA.
Anna M MorrisPathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health (NIOSH), Morgantown, WV 26505, USA.
Yong QianPathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health (NIOSH), Morgantown, WV 26505, USA.
Dhimiter BelloDepartment of Environmental Health, Center for Nanotechnology and Nanotoxicology, Harvard School of Public Health, Boston, MA 02115, USA; Department of Public Health, University of Massachusetts Lowell, MA 01854, USA. Electronic address: Dhimiter_Bello@uml.edu.
Philip DemokritouDepartment of Environmental Health, Center for Nanotechnology and Nanotoxicology, Harvard School of Public Health, Boston, MA 02115, USA. Electronic address: pdemokri@hsph.harvard.edu.

Funding

Translational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI JAIME ELIZABETH HART · 1985 to 2026
$44.6M
NIEHS NIH HHS P30 ES000002
6 · The paper itself

Abstract

Electronic cigarettes (e-cigs) have fast increased in popularity but the physico-chemical properties and toxicity of the generated emission remain unclear. Reactive oxygen species (ROS) are likely present in e-cig emission and can play an important role in e-cig toxicity. However, e-cig ROS generation is poorly documented. Here, we generated e-cig exposures using a recently developed versatile exposure platform and performed systematic ROS characterization on e-cig emissions using complementary acellular and cellular techniques: 1) a novel acellular Trolox-based mass spectrometry method for total ROS and hydrogen peroxide (H

Indexed as

Electronic Nicotine Delivery SystemsAntioxidantsCatalaseCell LineChromansEpithelial CellsHumansReactive Oxygen Species6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acidAntioxidantsCatalaseChromansReactive Oxygen SpeciesElectronic cigaretteNicotineOxidative stressReactive oxygen species

Identifiers

PMID29102637
PMCPMC5848214

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.