Evidence map›Paper›PMID 29102562›Full record

ArticleMolecular therapy : the journal of the American Society of Gene Therapy2018

Prostaglandin E

Garrett C Heffner, Melissa Bonner, Lauryn Christiansen, Francis J Pierciey, Dakota Campbell, Yegor Smurnyy, Wenliang Zhang, Amanda Hamel, Seema Shaw, Gretchen Lewis and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular therapy : the journal of the American Society of Gene Therapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed.

  1. Article
  2. Ex vivo modification of hematopoietic stem and progenitor cells for gene therapy.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Review
  3. Article
  4. Article
  5. Review
  6. Removal of innate immune barriers allows efficient transduction of quiescent human hematopoietic stem cells.Molecular therapy : the journal of the American Society of Gene Therapy · 2024
    Article
  7. Identification of a small molecule for enhancing lentiviral transduction of T cells.Molecular therapy. Methods & clinical development · 2023
    Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Evolution of Gene Therapy, Historical Perspective.Hematology/oncology clinics of North America · 2022
    Review
  19. Article
  20. Understanding and overcoming adverse consequences of genome editing on hematopoietic stem and progenitor cells.Molecular therapy : the journal of the American Society of Gene Therapy · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Garrett C Heffnerbluebird bio, Inc., 60 Binney Street, Cambridge, MA 02142, USA. Electronic address: gheffner@audentestx.com.
Melissa Bonnerbluebird bio, Inc., 60 Binney Street, Cambridge, MA 02142, USA.
Lauryn Christiansenbluebird bio, Inc., 60 Binney Street, Cambridge, MA 02142, USA.
Francis J Piercieybluebird bio, Inc., 60 Binney Street, Cambridge, MA 02142, USA.
Dakota Campbellbluebird bio, Inc., 60 Binney Street, Cambridge, MA 02142, USA.
Yegor Smurnyybluebird bio, Inc., 60 Binney Street, Cambridge, MA 02142, USA.
Wenliang Zhangbluebird bio, Inc., 60 Binney Street, Cambridge, MA 02142, USA.
Amanda Hamelbluebird bio, Inc., 60 Binney Street, Cambridge, MA 02142, USA.
Seema Shawbluebird bio, Inc., 60 Binney Street, Cambridge, MA 02142, USA.
Gretchen Lewisbluebird bio, Inc., 60 Binney Street, Cambridge, MA 02142, USA.
Kendrick A Gossbluebird bio, Inc., 60 Binney Street, Cambridge, MA 02142, USA.
Olivia GarijoDepartment of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA.
Bruce E TorbettDepartment of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA.
Holly Hortonbluebird bio, Inc., 60 Binney Street, Cambridge, MA 02142, USA.
Mitchell H Finerbluebird bio, Inc., 60 Binney Street, Cambridge, MA 02142, USA.
Philip D Gregorybluebird bio, Inc., 60 Binney Street, Cambridge, MA 02142, USA.
Gabor Veresbluebird bio, Inc., 60 Binney Street, Cambridge, MA 02142, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gene therapy currently in development for hemoglobinopathies utilizes ex vivo lentiviral transduction of CD34

Indexed as

Transduction, GeneticAnemia, Sickle CellAnimalsAntigens, CD34beta-ThalassemiaCell LineDinoprostoneGene LibraryGenetic TherapyGenetic VectorsGene Transfer TechniquesGlobinsHematopoietic Stem CellsHumansLentivirusLeukocyte Common AntigensAntigens, CD34DinoprostoneGlobinsLeukocyte Common Antigensgene therapyhematopoietic stem cellhemoglobinopathylentiviral vectorprostaglandin E(2)transductionvector copy number

Identifiers

PMID29102562
PMCPMC5763075

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.