ArticleJournal of Ayurveda and integrative medicine
Altitudinal variation of berberine, total phenolics and flavonoid content in Thalictrum foliolosum and their correlation with antimicrobial and antioxidant activities.
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24 citing papers in PubMed, 103 citations in OpenAlex.
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- Effect of cold arid high-altitude environment on bioactive phytochemical compounds of organically grown Brassicaceae vegetables for nutri-health security in mountainous regions.Scientific reports · 2024Article
- Chemical fingerprinting and multicomponent quantitative analysis for quality control ofHeliyon · 2024Article
- Discovery of quality markers ofFrontiers in pharmacology · 2024Article
- Review
- Antimicrobial activities and mechanisms of extract and components of herbs in East Asia.RSC advances · 2022Review
- Source dependent variation in phenolics, antioxidant and antimicrobial activity ofPhysiology and molecular biology of plants : an international journal of functional plant biology · 2022Article
- Pseudotargeted metabolomics revealed the adaptive mechanism ofFrontiers in plant science · 2022Article
- Current Evidence and Future Directions of Berberine Intervention in Depression.Frontiers in pharmacology · 2022Review
- Taify Pomegranate Juice (TPJ) Abrogates Acrylamide-Induced Oxidative Stress Through the Regulation of Antioxidant Activity, Inflammation, and Apoptosis-Associated Genes.Frontiers in veterinary science · 2022Article
- Antibacterial Activity ofIranian journal of medical sciences · 2020Article
- Evaluation of Two MajorMolecules (Basel, Switzerland) · 2020Article
- Solubility and Stability Advantages of a New Cocrystal of Berberine Chloride with Fumaric Acid.ACS omega · 2020Article
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4 authors at 1 institution in 1 country.
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Abstract
backgroundThe quality of herbal medicine is determined by its secondary metabolites, which may vary according to growth, season and altitude etc.
objectiveWe studied the variation in phytochemistry and biological activities of Thalictrum foliolosum (TF) roots collected from four sites at different altitudes. MATERIAL AND
methodsThe berberine content in different extracts of T. foliolosum roots collected from various altitudes was estimated using HPTLC. Total phenolic and flavonoid contents were determined using Folin-Ciocalteau reagent and aluminum chloride method respectively. The sensitivity of microbes for the extracts was studied using disc diffusion and the MIC was estimated using broth dilution method. Antioxidant capacity of the plant was studied using β-carotene bleaching assay, lipid peroxidation assay using goat liver, reducing power assay and DPPH free radical scavenging activity.
resultsBerberine content varied inversely with altitude; while phenol and flavonoid content of TF increased at higher altitudes. All the TF extracts showed moderate to high activity against Candida albicans, Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa. Extracts with high berberine content were most effective against C. albicans and S. aureus and also showed relatively significant anti-lipid peroxidation, β-carotene bleaching and reducing power. TF extracts with higher phenol and flavonoid content showed better scavenging of DPPH free radicals. Berberine was used as a standard in all the antioxidant and antimicrobial experiments performed.
conclusionThalictrum from lower elevations can be explored as an alternate source of berberine and the plant has high antioxidant and antimicrobial properties owing to its berberine content.
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