Evidence map›Paper›PMID 29102240›Full record

ReviewTrends in biotechnology2018

Emerging Biomedical Applications of Enzyme-Like Catalytic Nanomaterials.

David P Cormode, Lizeng Gao, Hyun Koo

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Trends in biotechnology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03678012 (Evaluation of Anti-biofilm Effects of Ferumoxytol), which is not on this map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03678012 early_phase1completednot on this map

Evaluation of Anti-biofilm Effects of Ferumoxytol (Feraheme) Using an in Situ Biofilm Demineralization Model

TypeinterventionalSponsorUniversity of PennsylvaniaRan2018 to 2018Enrolled16ConditionsDental CariesArmsFerumoxytol/Hydrogen peroxide, Hydrogen Peroxide, Water
3 · Its place in the literature

Who cites it

43 citing papers in PubMed.

  1. Review
  2. Co-assembled structures of FeTranslational cancer research · 2026
    Article
  3. Review
  4. Review
  5. Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Review
  11. Review
  12. Nanozyme-Based Robotics Approach for Targeting Fungal Infection.Advanced materials (Deerfield Beach, Fla.) · 2024
    Article
  13. Review
  14. Article
  15. Review
  16. Review
  17. Review
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

David P CormodeDepartment of Radiology, University of Pennsylvania, Philadelphia, PA, USA; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA; Department of Cardiology, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: david.cormode@uphs.upenn.edu.
Lizeng GaoInstitute of Translational Medicine, School of Medicine, Yangzhou University, Yangzhou, China.
Hyun KooBiofilm Research Labs, Levy Center for Oral Health, Department of Orthodontics, University of Pennsylvania, Philadelphia, PA, USA; Divisions of Pediatric Dentistry and Community Oral Health, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: koohy@upenn.edu.

Funding

Biofilm Elimination and Caries Prevention using Multifunctional NanocatalystsR01DE025848 · NIDCR · UNIVERSITY OF PENNSYLVANIA · PI KOO, HYUN · 2017 to 2025
$5.6M
Evaluation of a Novel Anti-Caries Approach to Modulate Virulence of S. mutansR01DE018023 · NIDCR · UNIVERSITY OF ROCHESTER · PI KOO, HYUN · 2008 to 2019
$3.4M
NIDCR NIH HHS R01 DE018023NIDCR NIH HHS R01 DE025848
6 · The paper itself

Abstract

Nanomaterials have been developed for many biomedical applications, including medical imaging, drug delivery, and antimicrobial coatings. Intriguingly, nanoparticles can display 'enzyme-like' activity and have been explored as alternatives to natural enzymes in several industrial and energy-related applications. Recently, these catalytic nanomaterials with enzyme-mimetic properties have found new biomedical applications, from biofilm disruption to protection against neurodegeneration and tumor prevention. In this review we focus on recent in vivo studies demonstrating potential therapeutic uses of catalytic nanomaterials. We also provide insights about the relationships between catalytic activity, therapeutic efficacy, and biocompatibility that are critical for clinical translatability. Finally, we discuss current challenges and future directions for the use of these nanomaterials as novel platforms for the development of sustainable, affordable, and safe therapeutics.

Indexed as

BiocatalysisNanostructuresHumansMolecular Medicinebiofilmcancercatalysisenzyme mimeticsimagingnanoparticles

Identifiers

PMID29102240
PMCPMC5738264

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.