Evidence map›Paper›PMID 29101741›Full record

ArticleDoklady. Biochemistry and biophysics2017

Cell-IQ visualization of motility, cell mass, and osteogenic differentiation of multipotent mesenchymal stromal cells cultured with relief calcium phosphate coating.

L S Litvinova, V V Shupletsova, K A Yurova, O G Khaziakhmatova, N M Todosenko, M Yu Khlusova, G B Slepchenko, E G Cherempey, Yu P Sharkeev, E G Komarova and 4 more

Abstract read
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In one paragraph

Article in Doklady. Biochemistry and biophysics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

L S LitvinovaImmanuel Kant Baltic Federal University, Kaliningrad, 236041, Russia. larisalitvinova@yandex.ru.
V V ShupletsovaImmanuel Kant Baltic Federal University, Kaliningrad, 236041, Russia.
K A YurovaImmanuel Kant Baltic Federal University, Kaliningrad, 236041, Russia.
O G KhaziakhmatovaImmanuel Kant Baltic Federal University, Kaliningrad, 236041, Russia.
N M TodosenkoImmanuel Kant Baltic Federal University, Kaliningrad, 236041, Russia.
M Yu KhlusovaSiberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, 634050, Russia.
G B SlepchenkoTomsk Polytechnic University, Tomsk, 634050, Russia.
E G CherempeyTomsk Polytechnic University, Tomsk, 634050, Russia.
Yu P SharkeevTomsk Polytechnic University, Tomsk, 634050, Russia.
E G KomarovaInstitute of Strength Physics and Materials Science, Siberian Branch, Russian Academy of Sciences, Tomsk, 634055, Russia.
M B SedelnikovaInstitute of Strength Physics and Materials Science, Siberian Branch, Russian Academy of Sciences, Tomsk, 634055, Russia.
V V MalashchenkoImmanuel Kant Baltic Federal University, Kaliningrad, 236041, Russia.
E S MelashchenkoImmanuel Kant Baltic Federal University, Kaliningrad, 236041, Russia.
I A KhlusovImmanuel Kant Baltic Federal University, Kaliningrad, 236041, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Cell-IQ continuous surveillance system allowed us to establish the following changes in a 14- day culture in vitro: a twofold suppression of the directional migration of multipotent mesenchymal stromal cells of human adipose tissue (MMSC-AT) towards the samples with a microarc calcium phosphate (CP) coating from synthetic hydroxyapatite; a tenfold decrease in the cell mass on the interphase with the samples, which was accompanied by a slight reduction in the expression of membrane determinants of stromal stem cells; and an enhancement of their osteogenic differentiation (osteocalcin secretion and mineralized matrix formation) on the 21st day of the study. Calcium phosphate particles, but not the calcium and phosphorus ions, may trigger the phenotypic transformation of the MMSC-AT behavior in vitro.

Indexed as

Adipose TissueCalcium PhosphatesCell DifferentiationCell MovementCells, CulturedHumansMesenchymal Stem CellsOsteocalcinOsteogenesiscalcium phosphateCalcium PhosphatesOsteocalcin

Identifiers

PMID29101741

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.