Evidence map›Paper›PMID 29101739›Full record

ReviewCurrent obesity reports2017

Brown Adipose Tissue: an Update on Recent Findings.

Kara L Marlatt, Eric Ravussin

Registry-linked trialOpen access · greenAbstract readReview
In one paragraph

Review in Current obesity reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06440122 (The Incidence and Outcomes of Metabolically Active Brown Adipose Tissue), which is not on this map. Cited by 118 papers.

0numbers the graph read from it
0cells of the map it votes in
118citing papers in PubMed
9.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06440122 unknown statusnot on this mapstarted 2024, after this paper: background citation

The Incidence and Outcomes of Metabolically Active Brown Adipose Tissue (aBAT) in Patients With Pheochromocytoma or Paraganglioma (PPGLs)

TypeobservationalSponsorKing's College Hospital NHS TrustRan2024 to 2024Enrolled100ConditionsPheochromocytoma, ParagangliomaArmsFDG-PET Scan
3 · Its place in the literature

Who cites it

118 citing papers in PubMed, 237 citations in OpenAlex.

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58 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Kara L MarlattPennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA, 70808, USA.
Eric RavussinPennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA, 70808, USA. eric.ravussin@pbrc.edu.
Pennington Biomedical Research Center · US

Funding

Research BaseP30DK072476 · NIDDK · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI Peter Todd Katzmarzyk · 2005 to 2026
$26.5M
Training in Obesity ResearchT32DK064584 · NIDDK · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI CORBY K MARTIN, Christopher D Morrison · 2003 to 2026
$5.3M
NIDDK NIH HHS P30 DK072476NIDDK NIH HHS T32 DK064584
6 · The paper itself

Abstract

purpose of reviewNew treatment approaches to weight loss and weight loss maintenance in humans are critical. Given its potential role in stimulating energy expenditure, brown adipose tissue (BAT) activation has become a trending topic as an anti-obesity treatment. RECENT

findingsMost studies on BAT stimulation have been conducted in rodents and used cold stimulation. To date, few human trials exist that tested the effect of cold exposure on BAT. Those studies show that BAT contributes a small amount to overall energy metabolism which is unlikely to cause weight loss. Nonetheless, improvements in glucose metabolism have been demonstrated in humans. While new pharmacological approaches demonstrate some contribution of BAT to overall energy expenditure, the potential cardiovascular risk (increased heart rate and blood pressure to sustain the extra energy expenditure) may preclude their use. There is no convincing evidence yet to indicate that BAT may be a viable pharmaceutical target for body weight loss or even weight loss maintenance. More research is needed to confirm the relevance of BAT and beige tissue to whole-body energy metabolism in humans.

Indexed as

AdiposityEnergy MetabolismThermogenesisAdipose Tissue, BrownAnimalsAnti-Obesity AgentsCold TemperatureCryotherapyHumansObesityTreatment OutcomeWeight LossAnti-Obesity AgentsBeigeBriteBrown adipose tissue, BATCapsaicinCapsinoidsCold acclimationCold exposureCold-induced thermogenesis, CITDiet-induced thermogenesis, DITEnergy balanceThermogenesisUncoupling protein 1, UCP1β3-adrenoreceptor agonists

Identifiers

PMID29101739
PMCPMC5777285
OpenAlexW2765987276

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.